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Topische Therapie des Harnblasenkarzinoms

  • Conference paper
Tagung 14.–17. Oktober 1987, Stuttgart

Part of the book series: Verhandlungsbericht der Deutschen Gesellschaft für Urologie ((VBDGUROLOGIE,volume 39))

  • 19 Accesses

Zusammenfassung

Multizentrische Therapiestudien werden durchgeführt, weil dem Forschenden immer mehr bewußt wird, daß zahlreiche Studien mit Fallzahlen publiziert werden, die klinisch relevante Unterschiede kaum erkennen lassen. Rekrutierungsphasen von mehr als 2–3 Jahren gefährden jedoch die Motivation der Teilnehmer und die erforderliche Einhaltung des Studienplans bezüglich Diagnostik, Therapie und Beobachtung, da sich der Erkenntnisstand rasch verändert [1]. Die Ergebnisse aus umfangreichen Patientenstichproben, die zudem aus Kliniken unterschiedlicher Regionen stammen, sind verallgemeinerbarer und damit aussagekräftiger. Dementsprechend ist die Akzeptanz der Ergebnisse multizentrischer Studien größer. Darüber hinaus dürften multizentrische Studien einen, wenn auch schwer zu messenden, positiven Einfluß auf die Qualität der Krankenversorgung in den beteiligten Kliniken haben. Sie schaffen schließlich günstige Voraussetzungen für die Umsetzung der Ergebnisse in die Routineversorgung.

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Literatur

  1. Whitemore WF Jr (1983) Management of invasive bladder neoplasms. Urology 1: 34

    Google Scholar 

  2. Bloom HJG, Hendry WF, Wallace DM, Skeet RG (1982) Treatment of T3 bladder cancer: controlled trial of preoperative radiotherapy and radical cystectomy versus radical radiotherapy. Br J Urol 54: 136

    Article  PubMed  CAS  Google Scholar 

  3. Rübben H, Lutzeyer W, Fischer N, Deutz F-J, Lagrange W, Giani G (1987) Natural history and treatment of low and high risk superficial bladder tumor (SBT). J Urol (in press)

    Google Scholar 

  4. Stoter G (1985) Chemotherapy for metastatic bladder carcinoma. World J Urol 3: 110

    Article  Google Scholar 

  5. Soloway M (1980) Rationale for intensive intravesical chemotherapy for superficial bladder cancer. J Urol 123: 461–466

    PubMed  CAS  Google Scholar 

  6. Huland H, Otto U, Droese M, Kloppel G (1984) Long-term mitomycin C instillation after transurethral resection of superficial bladder carcinoma: influence on recurrence progression and survival. J Urol 132: 27

    PubMed  CAS  Google Scholar 

  7. Morales A et al. (1976) Intracavitary bacillus Calmette-Guérin in the treatment of superficial bladder cancer. J Urol 116: 180–183

    PubMed  CAS  Google Scholar 

  8. Ruitenberg EJ et al. (1981) BCG preparations, cultured homogeneously dispersed or as surface pellicle, elicit different immunopotentiating effects but have similar antitumor activity in a murine fibrosarcoma. Cancer Immunol Immunother 11: 45–51

    Article  Google Scholar 

  9. Meijden van der APM et al. (1986) The effects of intravesical and intradermal application of a new BCG on the dog bladder. Urol Res 14: 207–210

    Article  Google Scholar 

  10. Schreinemachers LMH et al. BCG intravesical and intradermal application. A phase I study to the toxicity of a Dutch BCG preparation in patients with superficial bladder cancer. Eur Urol (in press)

    Google Scholar 

  11. Lamm DL et al. (1986) Complications of bacillus Calmette-Guérin immunotherapy in 1278 patients with bladder cancer. J Urol 135: 272–274

    PubMed  CAS  Google Scholar 

  12. Olsson CA, Chute R, Chadalawa NR (1973) Immunologic reduction of bladder cancer recurrence rate. Trans Am Assoc Gen Urin Surg 65: 66

    CAS  Google Scholar 

  13. Lamm DL, Reyna JA, Reichert DF (1981) Keyhole-limpet haemocyanin and immune ribonucleic acid immunotherapy of murine transitional cell carcinoma. Urol Res 9: 227–230

    Article  PubMed  CAS  Google Scholar 

  14. Olsson CA, Chute R, Rao CN (1973) Immunologic reduction of bladder cancer recurrence rate. J Urol 111: 173–176

    Google Scholar 

  15. Ikic D, Maricic Z, Oresic Vet al. (1981) Application of human leucocyte interferon in patients with urinary bladder papillomatosis, breast cancer and melanoma. Lancet 1: 1022

    PubMed  CAS  Google Scholar 

  16. Borden EC, Groveman DS, Nasu T et al. (1984) Antiproliferative activities of interferons against human bladder carcinoma cell lines in vitro. J Urol 132: 800–803

    PubMed  CAS  Google Scholar 

  17. Torti FM, Lum BL (1986) Superficial carcinoma of the bladder: natural history and the role of interferons. Sem Oncol 13: 3 (Suppl 2 ): 57–60

    Google Scholar 

  18. Scorticatti CH, La Pena NC, Bellora OG et al. (1982) Systemic IFN-alpha treatment of multiple grade I or II patients: pilot study. J Interferon Res 2: 339–343

    Article  PubMed  CAS  Google Scholar 

  19. Schröder FH et al. (1986) Therapie des oberflächlichen Urothelcarcinoms. Akt Urol 17: 6–9

    Article  Google Scholar 

  20. Huland H (1984) Otto U, Droese M, Klöppel G Long-term mitomycin instillation after transurethral resection of superficial bladder carcinoma: influence on recurrence. Progression and survival. J Urol 132: 27–29

    PubMed  CAS  Google Scholar 

  21. Heney NM, Ahmed S, Flanapen MJ, Frable W, Corder P, Hafermann N (1983) Superficial bladder cancer: progression and recurrence. J Urol 130: 1083–86

    PubMed  CAS  Google Scholar 

  22. Mishina T (1982) Chemoprophylaxe mit Mitomycin C bei Harnblasentumoren. In: Eisenberger F (Hrsg) Mitomycin Symposium: 21–50

    Google Scholar 

  23. Rassweiler J, Hath U, Bub P, Eisenberger F (1987) Intravesikale Langzeitchemoprophylaxe mit Mitomycin C beim oberflächlichen Harnblasenkarzinom. Rezidivverhalten und Progression nach 3 Jahren (im Druck)

    Google Scholar 

  24. Droller MJ, Erozan YS (1985) Thiotepa effects on urinary cytology in the interpretation of transitional cell cancer. J Urol 134: 671–674

    PubMed  CAS  Google Scholar 

  25. Koss LG (1979) Diagnostic Cytology. Lippincott, New York

    Google Scholar 

  26. Murphy WM, Soloway MS, Finebaum PJ (1981) Pathological changes associated with topical chemotherapy for superficial bladder cancer. J Urol 126: 461–464

    PubMed  CAS  Google Scholar 

  27. Murphy WM, Soloway MS, Chiou Jin Lin BS (1976) Morphologic effects of thiotepa on mouse urothelium. Acta Cytol 21: 701–704

    Google Scholar 

  28. Rasmussen K, Peterson BL, Jacobo E, Penick GD, Sall J (1980) Cytologic effects of thiotepa and adriamycin on normal canine urothelium. Acta Cytol 24: 237–243

    PubMed  CAS  Google Scholar 

  29. Schumann GB (1980) Urine sediment exmination. Williams & Wilkins, Baltimore

    Google Scholar 

  30. Voogt de HJ, Rathert P, Beyer-Boon (1979) Praxis der Urinzytologie. Springer, Berlin Heidelberg New York

    Book  Google Scholar 

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Author information

Authors and Affiliations

  1. Biometrisches Zentrum für Therapiestudien GmbH, Pettenkoferstr. 35, D-8000, München 2, Deutschland

    Dr. rer. biol. hum., Dipl.-Inform. Med. Dorle Messerer

  2. Abt. Urologie, Knappschaftskrankenhaus Bardenberg, Dr.-Hans-Böckler-Platz 1, D-5102, Würselen/Bardenberg, Deutschland

    Priv.-Doz. Dr. med. H. Rübben

  3. Kliniek voor Urologie, Katholieke Universiteit Nijmegen, Postbus 9101, NL-6500 HB, Nijmegen, Niederlande

    Prof. Dr. F. M. J. Debruyne

  4. Allgemeines Krankenhaus Celle, Siemensplatz 4, D-3100, Celle, Deutschland

    C. D. Jurincic

  5. Urologie der Krankenanstalt Rudolfstiftung, Juchgasse 25, A-1030, Wien, Österreich

    OA Dr. W. Höltl

  6. Urologische Klinik und Poliklinik der TU München, Klinikum rechts der IsarDeutschland, Ismaningerstr.22, D-8000, München 80, Deutschland

    Dr. H. Leyh

  7. Urologische Klinik, KatharinenhospitalDeutschland, D-7000, Stuttgart 1, Deutschland

    Ursula Hath

  8. Abt. Urologie, Krankenanstalten Düren, Akademisches Lehrkrankenhaus, Roonstr. 30, D-5160, Düren, Deutschland

    Dr. St. Roth

  9. Urologische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Deutschland

    Dr. H. van Ahlen

  10. Urologische Universitätsklinik, Inselspital, CH-3010, Bern, Schweiz

    Priv.-Doz. Dr. med. U. E. Studer

Authors
  1. Dr. rer. biol. hum., Dipl.-Inform. Med. Dorle Messerer
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  2. J. Hasford
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  3. Priv.-Doz. Dr. med. H. Rübben
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  4. L. Weißbach
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  5. L. Knebel
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  6. F.-J. Deutz
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  7. R. Friedrichs
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  8. Prof. Dr. F. M. J. Debruyne
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  9. A. P. M. van der Meijden
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  10. M. J. W. van Leeuwen
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  11. C. D. Jurincic
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  12. K. F. Klippel
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  13. OA Dr. W. Höltl
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  14. R. Hasun
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  15. W. Albrecht
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  16. M. Marberger
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  17. Dr. H. Leyh
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  18. Ursula Hath
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  19. J. Rassweiler
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  20. F. Eisenberger
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  21. Dr. St. Roth
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  22. P. Rathert
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  23. Dr. H. van Ahlen
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  24. R. M. Schaefer
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  25. Priv.-Doz. Dr. med. U. E. Studer
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  26. Ch. Wüthrich
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  27. M. Schnyder v. W.
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  28. D. Ackermann
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Consortia

die urologische Arbeitsgruppe Süd-Ost Niederlande und die EORTC GU-Group, Urologische Abteilung, Universitätsklinik Nijmegen, Niederlande

Editor information

Editors and Affiliations

  1. Moorenstr. 5, D-4000, Düsseldorf, Deutschland

    Rolf Ackermann (Direktor der Urologischen Klinik und Poliklinik der Universität Düsseldorf) (Direktor der Urologischen Klinik und Poliklinik der Universität Düsseldorf)

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© 1988 Springer-Verlag Berlin Heidelberg

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Messerer, D. et al. (1988). Topische Therapie des Harnblasenkarzinoms. In: Ackermann, R. (eds) Tagung 14.–17. Oktober 1987, Stuttgart. Verhandlungsbericht der Deutschen Gesellschaft für Urologie, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83404-2_17

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  • DOI: https://doi.org/10.1007/978-3-642-83404-2_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19042-4

  • Online ISBN: 978-3-642-83404-2

  • eBook Packages: Springer Book Archive

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