Immunologic Abnormalities Following Hemorrhage and Trauma
Despite rigorous prophylactic therapy and the availability of a variety of increasingly powerful antimicrobial agents, infections are the major cause of mortality and morbidity after traumatic injury and burns [1, 2]. It has been estimated in different studies [3, 4] that from 60 to 88% of deaths occurring more than 7 days after blunt trauma or thermal injury were caused by sepsis. These infectious episodes following injury generally are characterized by multiple organ system failure (MOSF). Pulmonary processes either directly related to infection, such as Pseudomonas aeruginosa pneumonia, or secondarily caused by infection, such as the adult respiratory distress syndrome (ARDS), are invariably a major aspect of the post-injury MOSF.
KeywordsLymphocyte Proliferation Suppressor Cell Thermal Injury Adult Respiratory Distress Syndrome Immunologic Abnormality
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- 7.Altura BM (1983) Endothelium, reticuloendothelial cells, and microvascular integrity: roles in host defense. In: Altura BM, Lefer AM, Schumer W (eds) Handbook of shock and trauma. Raven Press, New York, pp 51–95.Google Scholar
- 8.Saba TM, Lanser ME, Dillon BC (1983) Opsonic fibronectin and phagocytic defense after trauma. In: Altura BM, Lefer AM, Schumer W (eds) Handbook of shock and trauma. Raven Press, New York, pp 167–181.Google Scholar
- 11.Hesselvek S, Brodin B, Carlsson C, Cedergren B, Gorfeldt L, Lieden J (1987) Cryoprecipitate infusion fails to improve organ function in septic shock. Crit Care Med 15:473–483.Google Scholar
- 13.Meakins JL, McLean APH, Kelly R, et al (1982) Delayed hypersensitivity and neutrophil Chemotaxis: effect of trauma. J Trauma 20:833–839.Google Scholar
- 22.Kupper TS, Green DR (1984) Immunoregulation after thermal injury: sequential appearance of I-J +, LY-1 T suppressor inducer cells and LY-2 T suppressor effector cells following thermal trauma in mice. J Immunol 136:3047–3053.Google Scholar
- 25.Abraham E, Chang Y-H (1987) Effects of hemorrhage and hemorrhagic serum on macrophage and T cell function. Clin Res 35:383A.Google Scholar