Immunologic Abnormalities Following Hemorrhage and Trauma
Despite rigorous prophylactic therapy and the availability of a variety of increasingly powerful antimicrobial agents, infections are the major cause of mortality and morbidity after traumatic injury and burns [1, 2]. It has been estimated in different studies [3, 4] that from 60 to 88% of deaths occurring more than 7 days after blunt trauma or thermal injury were caused by sepsis. These infectious episodes following injury generally are characterized by multiple organ system failure (MOSF). Pulmonary processes either directly related to infection, such as Pseudomonas aeruginosa pneumonia, or secondarily caused by infection, such as the adult respiratory distress syndrome (ARDS), are invariably a major aspect of the post-injury MOSF.
KeywordsDepression Corticosteroid Pneumonia Cortisol Heparin
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