Update 1988 pp 701-705 | Cite as

Management of Hypotonic Hyponatremia

  • G. Decaux
  • S. Brimioulle
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 5)


The management of hypotonic hyponatremia depends on its cause and its severity. The cases of hyponatremia with decreased, increased and normal extracellular fluid (ECF) volumes will be examined, followed by a brief mention concerning severe hyponatremia.


Antidiuretic Hormone Angiotensin Converting Enzyme Hypertonic Saline Urine Osmolality Nephrogenic Diabetes Insipidus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dzau VJ, Hollenberg NK (1984) Renal response to Captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia. Ann Intern Med 100:777–781.PubMedGoogle Scholar
  2. 2.
    Packer M, Medina N, Yushak M (1984) Correction of dilutional hyponatremia in severe chronic heart failure by converting-enzyme inhibition. Ann Intern Med 100:782–788.PubMedGoogle Scholar
  3. 3.
    Cauchie P, Vincken W, Decaux G (1987) Urea treatment for water retention in hyponatremic congestive heart failure. Int J Cadiol 17:102–104.CrossRefGoogle Scholar
  4. 4.
    Carrilho F, Bosh J, Arroyo V, Mas A, Viver J, Rodes J (1977) Renal failure associated with demeclocycline in cirrhosis. Ann Intern Med 87:195–197.PubMedGoogle Scholar
  5. 5.
    Decaux G, Mols P, Cauchie P, Flamion B, Delwiche F (1986) Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. Nephron 44:337–343.PubMedCrossRefGoogle Scholar
  6. 6.
    Bartter FC, Schwartz WB (1967) The syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Am J Med 42:790–806.PubMedCrossRefGoogle Scholar
  7. 7.
    Tanay A, Yust I, Peresecenschi G, Abramov AL, Aviram A (1979) Long-term treatment of the syndrome of inappropriate antidiuretic hormone secretion with phenytoin. Ann Intern Med 90:50–52.PubMedGoogle Scholar
  8. 8.
    Forrest JN, Cox M, Hong C, Morrison G, Bia M, Singer I (1978) Superiority of demeclocy-cline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med 298:173–177.PubMedCrossRefGoogle Scholar
  9. 9.
    Hofbauer KG, Mah SC (1987) Vasopressin antagonists: present and future. Kidney Int 32 (suppl):S76–S82.Google Scholar
  10. 10.
    Singer L, Rotenberg D (1973) Demeclocycline induced nephrogenic diabetes insipidus: in vitro and in vivo studies. Ann Intern Med 79:679–683.PubMedGoogle Scholar
  11. 11.
    Miller PD, Linas SL, Scrier RW (1980) Plasma demeclocycline levels and nephrotoxicity. JAMA 243:2513–2515.PubMedCrossRefGoogle Scholar
  12. 12.
    Decaux G, Brimioulle S, Genette F, Mockel J (1980) Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with urea. Am J Med 69:99–106.PubMedCrossRefGoogle Scholar
  13. 13.
    Decaux G, Genette Fr (1981) Urea for long-term treatment of the syndrome of inappropriate secretion of antidiuretic hormone. Br Med J 283:1081–1083.CrossRefGoogle Scholar
  14. 14.
    Decaux G, Waterlot Y, Genette Fr, Hallemans R, Demanet JC (1982) Inappropriate secretion of antidiuretic hormone treated by furosemide. Br Med J 285:89–90.CrossRefGoogle Scholar
  15. 15.
    Decaux G (1983) Treatment of the syndrome of inappropriate secretion of antidiuretic hormone by long loop diuretics. Nephron 35:82–88.PubMedCrossRefGoogle Scholar
  16. 16.
    Decaux G, Szypoer M, Grivegnée A (1983) Cerebral ventricular volume during hyponatremia. J Neurol Neurosurg Psychiatry 46:443–445.PubMedCrossRefGoogle Scholar
  17. 17.
    Ashraf N, Locksley R, Arieff A (1981) Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients. Am J Med 70:1163–1168.PubMedCrossRefGoogle Scholar
  18. 18.
    Hatman D, Rossier B, Zohlman R, Schrier R (1973) Rapid correction of hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone: an alternative treatment to hypertonic saline. Ann Intern Med 78:870–875.Google Scholar
  19. 19.
    Ayus JC, Krothapalli RK, Arieff AI (1982) Rapid correction of severe hyponatremia with intravenous hypertonic saline solution. Am J Med 72:43–48.PubMedCrossRefGoogle Scholar
  20. 20.
    Decaux G, Unger J, Brimioulle S, Mockel J (1982) Hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone: rapid correction with urea, sodium chloride, and water restriction therapy. JAMA 247:471–474.PubMedCrossRefGoogle Scholar
  21. 21.
    Kleinschmidt-De Masters BK, Norenberg MD (1981) Rapid correction of hyponatremia causes demyelinization: relation to central pontine myelinolysis. Science 211:1068–1070.CrossRefGoogle Scholar
  22. 22.
    Loreno R (1983) Central pontine myelinolysis following rapid correction of hyponatremia. Ann Neurol 13:232–242.CrossRefGoogle Scholar
  23. 23.
    Sterns RH, Riggs JE, Schichet SS (1986) Osmotic demyelination following correction of hyponatremia. N Engl J Med 314:1535–1541.PubMedCrossRefGoogle Scholar
  24. 24.
    Dubois GD, Arieff AI (1984) Symptomatic hyponatremia: the case for rapid correction. In: Narins RS (ed) Controversies in nephrology and hypertension. Churchill-Livingstone, New York, pp 393–407.Google Scholar
  25. 25.
    Ayus JC, Krothapalli R, Armstrong DL (1985) Rapid correction of severe hyponatremia in the rat: Histopathological changes in the brain. Am J Physiol 248:F711–F719.PubMedGoogle Scholar
  26. 26.
    Ayus JC, Krothapalli RK, Arieff AI (1987) Treatment of symptomatic hyponatremia and its relation to brain damage: A prospective study. N Engl J Med 317:1190–1195.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. Decaux
  • S. Brimioulle

There are no affiliations available

Personalised recommendations