Update 1988 pp 293-302 | Cite as

Reperfusion Arrhythmias: An Update

  • J. R. Parratt
  • C. L. Wainwright
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 5)

Abstract

Tennant & Wiggers [1] were the first to clearly demonstrate that reperfusion of the ischemic myocardium can be associated with the generation of potentially malignant ventricular arrhythmias. The importance of such arrhythmias has been recognized for many years during surgical reperfusion of the whole heart (e.g. cardiopulmonary bypass with ischemic arrest) but has recently taken on renewed significance because of the interest in thrombolyic therapy for patients with acute myocardial infarction, the establishment of the concept of transient coronary artery spasm with platelet aggregation as one cause of angina pectoris and the evidence suggesting that reperfusion-induced ventricular fibrillation is one cause of sudden cardiac death. The significance of reperfusion arrhythmias in these particular clinical situations has led to a great deal of experimental work to determine precisely under what conditions these potentially lifethreatening arrhythmias arise and how they may be suppressed by drugs. This update attempts to summarize the main factors responsible.

Keywords

Ischemia Aspirin Cardiol Propranolol Plasminogen 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. R. Parratt
  • C. L. Wainwright

There are no affiliations available

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