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HLA in Narcolepsy in France

  • M. Billiard
  • J. Seignalet
  • H. Betuel
  • A. Marcadet
  • L. Gebuhrel
  • A. C. Freidel
  • C. Confavreux
  • A. Besset
  • J. Cadilhac

Abstract

The genetic aspect of narcolepsy in man has long been considered, with the first report of a positive family history of narcolepsy made by Westphal (1877) even before the term “narcolepsy” was coined by Gelineau (1880). Since then a number of series have been published showing variable rates of probands with a positive family history of narcolepsy and suggesting either an autosomal dominant mode of inheritance with incomplete penetrance (Krabbe and Magnussen 1942; Daly and Yoss 1959; Baraitser and Parkes 1978) or a two-threshold multifactorial system (Nevsimalova-Bruhova and Roth 1972; Kessler 1976; Honda et al. 1983 a).

Keywords

Multiple Sleep Latency Test Restriction Endonuclease Fragment Autosomal Dominant Mode Narcoleptic Patient Typical Narcolepsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. Billiard
  • J. Seignalet
  • H. Betuel
  • A. Marcadet
  • L. Gebuhrel
  • A. C. Freidel
  • C. Confavreux
  • A. Besset
  • J. Cadilhac

There are no affiliations available

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