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Immunological Features of Narcolepsy in Japan

  • K. Matsuki
  • T. Juji
  • Y. Honda

Abstract

Narcolepsy has traditionally been regarded as a nonimmunological disease. However, the findings of a strong association between narcolepsy and an HLA antigen have led to a new speculation: an altered regulatory system of immune response may underlie the pathogenesis of narcolepsy (Billiard and Seignalet 1985; Matsuki et al. 1985; Langdon et al. 1986).

Keywords

Daytime Sleepiness Lymphocyte Subset Stimulation Index Lymphocyte Subpopulation Immunological Feature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bertrams J, Luboldt W, Dannehl K, Baur MP (1986) Homogeneity of HLA-DQ, DR phenotypes in lymphocyte subsets of normal individuals. Hum Immunol 15: 330–335PubMedCrossRefGoogle Scholar
  2. Billiard M, Seignalet J (1985) Extraordinary association between HLA-DR2 and narcolepsy. Lancet i: 226–227CrossRefGoogle Scholar
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  4. Langdon N, Lock C, Welsh K, Vergani D, Dorow R, Wachtel H, Palenschat D, Parkes JD (1986) Immune factors in narcolepsy. Sleep 9: 143–148PubMedGoogle Scholar
  5. Matsuki K, Honda Y, Naohara T, Satake M, Someya T, Harada S, Juji T (1985) Lymphocyte subsets in HLA-DR2-positive narcoleptic patients. Folia Psychiatr Neurol Jpn 39: 499–506PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • K. Matsuki
  • T. Juji
  • Y. Honda

There are no affiliations available

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