Positive HLA-Dw2 in Narcolepsy

  • T. Naohara
  • Y. Honda
  • T. Juji


Some authors reported that all the narcoleptic patients studied were positive for HLA-DR2 and DQw1 (Honda et al. 1984; Juji et al. 1984; Langdom et al. 1984; Billiard and Seignalet 1985). These findings prompted us to investigate HLA-D specificities of narcoleptics, because, in the Japanese population, HLA-D specificities that associate with HLA-DR2 have been reported to be HLA-Dw12 and less frequently Dw2, which is in contrast to the high correlation of HLA-DR2 and HLA-Dw2 (r value is approximately 0.9) in Caucasoid populations (Jaraquemada 1984).


Gray Zone Mixed Lymphocyte Reaction Narcoleptic Patient Caucasoid Population Autologous Mixed Lymphocyte Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Amos DB, Bach FH (1968) Phenotypic expressions of the major histocompatibility locus in man (HL-A): leukocyte antigens and mixed leukocyte culture reactivity. J Exp Med 128: 623–637PubMedCrossRefGoogle Scholar
  2. Bach FH (1985) The HLA class II genes and products: the HLA-D region. Immunol Today 6: 89–94CrossRefGoogle Scholar
  3. Bain B, Vas MR, Lowenstein L (1964) The development of large immature mononuclear cells in mixed leukocyte culture. Blood 23: 108–116PubMedGoogle Scholar
  4. Bauer MP, Neugebauer M, Deppe H, Sigmund M, Luton T, Mayr WR, Albert ED (1984) Population analysis on the basis of deduced haplotypes from random families. In: Albert ED, Baur MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg New York, pp 333–341Google Scholar
  5. Billiard M, Seignalet J (1985) Extraordinary association between HLA-DR2 and narcolepsy. Lancet i: 226–227CrossRefGoogle Scholar
  6. Cohen N, Amar A, Brautbar C (1984) Definition of a new DR2 short associated HLA-D specificity with the ninth histocompatibility workshop reagents. Tissue Antigens 24: 184–186PubMedCrossRefGoogle Scholar
  7. Dupont B, Hansen JA, Yunis EJ (1976) Human mixed-lymphocyte culture reaction: genetics, specificity, and biological implications. Adv Immunol 23: 107–202PubMedCrossRefGoogle Scholar
  8. Hardy DA, Bell JI, Long EO, Lindsten T, McDevitt HO (1986) Mapping of the class II region of the human major histocompatibility complex by pulse field gel electrophoresis. Nature 323: 453–455PubMedCrossRefGoogle Scholar
  9. Honda Y, Doi Y, Juji T, Satake M (1984) Narcolepsy and HLA: positive DR2 as a prerequisite for the development of narcolepsy. Folia Psychiatr Neurol Jpn 38: 360Google Scholar
  10. Jaraquemada D, Okoye R, Ollier W, Awad J, Festenstein H (1984) HLA-D and DR in different populations. In: Albert ED, Baur MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg New York, pp 472–473Google Scholar
  11. Jaraquemada D, Navarrete C, Ollier W, Awad J, Okoye R, Festenstein H (1986) HLA-D specificity assignments are independent of HLA-DQ, HLA-DR and other class II specificities and define a biologically important segregant series which strongly activates a functionally distinct T cell subset. Hum Immunol 16: 259–270PubMedCrossRefGoogle Scholar
  12. Juji T, Satake M, Honda Y, Doi Y (1984) HLA antigens in Japanese patients with narcolepsy. Tissue Antigens 24: 316–319PubMedCrossRefGoogle Scholar
  13. Langdon N, Dam MV, Welsh KI, Vaughan R, Parkes D (1984) Genetic markers in narcolepsy. Lancet ii: 1178–1180Google Scholar
  14. Marcadet A, Gebuhrer L, Betuel H, Seignalet J, Freidel AC, Confavreux C, Billiard M, Dausset J, Cohen D (1985) DNA polymorphism related to HLA-DR2 Dw2 in patients with narcolepsy. Immunogenetics 22: 679–683PubMedCrossRefGoogle Scholar
  15. Mempel W, Grosse-Wilde H, Baumann P, Netzel B, Steinbauer-Rosenthal I, Scholoz S, Bertrams J, Albert ED (1973b) Population genetics of the MLC response: typing for MLC determinants using homozygous and heterozygous reference cells. Transplant Proc 5: 1529–1534PubMedGoogle Scholar
  16. Ollier W, Doxiadis I, Jaraquemada D, Okoye R, Grosse-Wilde H, Festenstein H (1984) First level of HLA-D “blank” HTC. In: Albert ED, Baur MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg New York, pp 291–285Google Scholar
  17. Ryder LP, Thomsen M, Platz P, Svejgaard A (1975) Data reduction in LD-typing. In: Kissmeyer-Nielsen F (ed) Histocompatibility testing 1975. Munksgaard, Copenhagen, pp 557–562Google Scholar
  18. Sasazuki T, McMichael A, Payne R, McDevitt HO (1977) HLA-D antigens in the Japanese population. Tissue Antigens 9: 267–272PubMedCrossRefGoogle Scholar
  19. Sasazuki T, Kaneoka H, Tsuji K, Nose Y, Kashiwagi N, Kaneko T (1980) HLA-D in Japan. In: Terasaki PI (ed) Histocompatibility testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, pp 274–276Google Scholar
  20. Schrek R, Donnelly WJ (1961) Differences between lymphocytes of leukemic and nonleukemic patients with respect to morphologic features, motility, and sensitivity to guinea pig serum. Blood 18: 561–571Google Scholar
  21. Schreuder GMT, Degos L (1984) HLA-DR, DQ and DW relationships. In: Albert ED, Baur MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg New York, p 243Google Scholar
  22. Yunis EJ, Amos DB (1971) Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci USA 68: 3031–3035PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • T. Naohara
  • Y. Honda
  • T. Juji

There are no affiliations available

Personalised recommendations