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Protein-Induced DNA Bending

  • A. A. Travers
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 2)

Abstract

The tight bending of DNA is a ubiquitous feature, both of chromosomal structure and also of nucleoprotein complexes involved in the enzymatic manipulation of DNA. In these structures the DNA follows a defined three-dimensional path — or configuration. However, the DNA double helix does not behave as an isotropic rod. Instead, the structural and mechanical properties of DNA vary in a sequence-dependent manner resulting in a molecule which is flexurally anisotropic (Calladine and Drew 1986). Thus, the sequence of the DNA molecule determines its preferred configuration, and hence its ability to wrap around a protein core. This ability to assume a particular configuration we term bendability which is thus a property which reflects the conformational rigidity or flexibility of individual short sequences contained within a longer defined sequence.

Keywords

Minor Groove Groove Width Sequence Preference Sequence Periodicity Intrinsic Curvature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. A. Travers
    • 1
  1. 1.MRC Laboratory of Molecular BiologyCambridgeUK

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