Protein-Induced DNA Bending
The tight bending of DNA is a ubiquitous feature, both of chromosomal structure and also of nucleoprotein complexes involved in the enzymatic manipulation of DNA. In these structures the DNA follows a defined three-dimensional path — or configuration. However, the DNA double helix does not behave as an isotropic rod. Instead, the structural and mechanical properties of DNA vary in a sequence-dependent manner resulting in a molecule which is flexurally anisotropic (Calladine and Drew 1986). Thus, the sequence of the DNA molecule determines its preferred configuration, and hence its ability to wrap around a protein core. This ability to assume a particular configuration we term bendability which is thus a property which reflects the conformational rigidity or flexibility of individual short sequences contained within a longer defined sequence.
KeywordsMinor Groove Groove Width Sequence Preference Sequence Periodicity Intrinsic Curvature
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