DNA Repair by the Ada Protein of E. coli

  • P. Karran
  • J. Hall
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 2)

Abstract

The Ada protein of E. coli exemplifies the highly specialized nature of the enzymes which have evolved to repair DNA. This protein exhibits not only novel mechanistic features but also provides an apparently unique example of a strategy for controlling gene expression in E. coli. Furthermore, knowledge of the properties and mode of action of the Ada protein has afforded insight into how human cells are affected by alkylating agents, including those used in chemotherapy.

Keywords

Toxicity Cysteine Proline Polypeptide Thiol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. Karran
    • 1
  • J. Hall
  1. 1.Imperial Cancer Research FundClare Hall LaboratoriesSouth Mimms, HertsUK

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