DNA Repair by the Ada Protein of E. coli
The Ada protein of E. coli exemplifies the highly specialized nature of the enzymes which have evolved to repair DNA. This protein exhibits not only novel mechanistic features but also provides an apparently unique example of a strategy for controlling gene expression in E. coli. Furthermore, knowledge of the properties and mode of action of the Ada protein has afforded insight into how human cells are affected by alkylating agents, including those used in chemotherapy.
KeywordsAdaptive Response Alkylating Agent alkB Gene Imperial Cancer Research Fund Methyl Transfer Reaction
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