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DNA Repair and Skin Disease

  • Conference paper
Dermatology in Five Continents

  • 123 Accesses

Abstract

Along with replication and transcription, DNA repair should be considered as a normal cellular process. In addition to cellular differentiation, DNA repair may be affected by inborn errors and by exogenous effects as well. In terminally differentiating structures such as epidermis, an alteration of DNA repair entails decrease of activity or retardation of repair processes leading to cytotoxic, mutagenic and oncogenic events under exogenous hazards (such as UV, chemicals, X-ray etc.). Fibroblasts show the UV-induced defect like that in cultured keratinocytes (Kondo). Atrophy, dyspigmentation and tumors are the epidermal endpoints of these events whereas actinic elastosis appears on the dermal level. The heterogenous group of xeroderma pigmentosum (XP) is the best-known and most well-investigated model of a congenital defect of DNA repair and its devasting effects on the skin after UV irradiation. XP is observed in all continents and races. Nevertheless, there are regional differences between the nine subgroups of classical XP A-I and the variant type.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Mannheim Medical School, University of Heidelberg, Mannheim, FR Germany

    E. G. Jung (Chairman)

  2. School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    Y. Satoh (Co-Chairman)

  3. Faculty of Medicine, Air Shams University, Cairo, Egypt

    M. H. El-Hefnawi (Co-Chairman)

  4. Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan

    S. Kondo

  5. Department of Dermatology, Kobe University School of Medicine, Kobe, Japan

    M. Ichihashi

Authors
  1. E. G. Jung
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  2. Y. Satoh
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  3. M. H. El-Hefnawi
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  4. S. Kondo
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  5. M. Ichihashi
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Editor information

Editors and Affiliations

  1. Universitäts-Hautklinik und Poliklinik, Klinikum Steglitz der Freien Universität, Hindenburgdamm 30, D-1000, Berlin 45, Federal Republic of Germany

    Constantin E. Orfanos (CMD — Scientific Secretariat), Rudolf Stadler (CMD — Scientific Secretariat) & Harald Gollnick (CMD — Scientific Secretariat) (CMD — Scientific Secretariat),  (CMD — Scientific Secretariat) &  (CMD — Scientific Secretariat)

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© 1988 Springer-Verlag Berlin Heidelberg

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Jung, E.G., Satoh, Y., El-Hefnawi, M.H., Kondo, S., Ichihashi, M. (1988). DNA Repair and Skin Disease. In: Orfanos, C.E., Stadler, R., Gollnick, H. (eds) Dermatology in Five Continents. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83360-1_81

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  • DOI: https://doi.org/10.1007/978-3-642-83360-1_81

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83362-5

  • Online ISBN: 978-3-642-83360-1

  • eBook Packages: Springer Book Archive

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