Epidermal Cytokines

  • T. A. Luger
  • J. C. Ansel
  • T. Baba
Conference paper


The concept of the skin as an passive element in immune mediated reactions has been changed recently and it became clear that particularly the epidermis actively participates in various immunological processes. It is well established that dendritic bone marrow derived epidermal cells such as Langerhans cells play an important role in epidermal cell, antigen specific and allogenic T cell activation [1]. Another very recently discovered dendritic epidermal cell apparently belongs to the T cell lineage and exhibits natural killer cell activities [2]. Moreover it became evident that in addition to these immunocompetent epidermal cells the keratinocytes are capable of releasing immunoregulating mediators also named cytokines [3, 4].


Epidermal Cell Graft Versus Host Disease Natural Killer Cell Activity Phorbol Myristate Acetate Human Epidermal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • T. A. Luger
    • 1
  • J. C. Ansel
    • 2
  • T. Baba
    • 3
  1. 1.Department of Dermatology II, Laboratory for Cell BiologyUniversity of Vienna and Ludwig Boltzmann Institute for Dermatovenerologic SerodiagnosisViennaAustria
  2. 2.Veterans Administration Medical CenterDermatology ServicePortlandUSA
  3. 3.Institute of Clinical Medical SciencesThe University of TsukubaIbarakiJapan

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