As an introduction, Dr. Nicholas A. Soter (USA) opened the symposium by noting that experimental studies in animal models and in humans suggest that the tissue deposition of circulating immune complexes or the local formation of immune complexes in situ are central events in the production of necrotizing vasculitis. The mechanisms of the localization of circulating immune complexes to a specific vessel site are related in part to vasoactive amines and subsequent vasopermeability alterations. Additional factors may include the participation of endothelial cell-surface receptors, abnormalities in the clearance of immune complexes by the reticuloendothelial system, and turbulence at blood vessel bifurcations. The identification of antigens in vasculitis has been accomplished in only a few conditions, notably certain infections and drugs.
KeywordsPermeability Arthritis Ischemia Histamine Hydrochloride
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