Retinoids — Present Status

  • G. L. Peck
  • A. Vahlquist
  • H. Gollnick
  • W. J. Cunliffe
  • A. R. Shalita
Conference paper


With the dramatic response of severe cystic acne, psoriasis, many of the disorders of keratinization, and the wide spectrum of other benign and malignant conditions reported to be partially responsive, the synthetic retinoids have ushered in a new era in the therapy of skin disease. In particular, isotretinoin and etretinate, either used alone or in combination with other agents, have been the most commonly used synthetic retinoids during the past decade.


Bullous Pemphigoid Diffuse Idiopathic Skeletal Hyperostosis Synthetic Retinoid Oral Retinoid Retinoid Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Peck GL, Olsen TG, Yoder FW et al. (1979) Prolonged remission of cystic acne with 13-cis retinoic acid. N Engl J Med 300:329–333.PubMedCrossRefGoogle Scholar
  2. 2.
    Shalita AR, Cunningham WJ, Leyden JJ et al. (1983) Isotretinoin treatment of acne and related disorders. An Update. J Am Acad Derm 9:629–638.CrossRefGoogle Scholar
  3. 3.
    Leyden JJ (1985) Paper presented at the Retinoid Symposium, American Academy of Dermatology, December.Google Scholar
  4. 4.
    Ellis CN, Gold RC, Grekin RC et al. (1982) Etretinate therapy stimulates deposition of mucus-like material in epidermis of patients with psoriasis. Am Acad Derm 6:699–704.CrossRefGoogle Scholar
  5. 5.
    Weleber RG, Dennon ST, Hanifim JM et al. (1986) Abnormal retinal function associated with isotretinoin therapy for acne. Arch Phthalmol 104:831–837.CrossRefGoogle Scholar
  6. 6.
    Lammer EJ, Chen DT, Hoer RN et al. (1985) Retinoic acid embryopathy. N Engl J Med 313:837–841.PubMedCrossRefGoogle Scholar
  7. 7.
    Bershad S, Rubinstein A, Paterniti JR et al. (1985) Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne. N Engl J Med 313:981–985.PubMedCrossRefGoogle Scholar
  8. 8.
    Golnick H, Schwartzkopff W, Luley C, Orfanos CE (1982) Alterations of lipid metabolism under treatment with oral retinoids (isotretinoin and etretinate). In: Färber EM, Cox AJ (eds) Psoriasis Proceedings of the Third International Syposium. Grune and Stratton, New York, pp 479–486.Google Scholar
  9. 9.
    Vahlquist A, Loof L, Nordlinder H et al. (1985) Differential hepatotoxocity of two oral retinoids (etretinate and isotretinoin) in a patient with Palmoplantar psoriasis. Acta Derm Venereol (Stockh) 65:359–362.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. L. Peck
    • 1
  • A. Vahlquist
    • 2
  • H. Gollnick
    • 3
  • W. J. Cunliffe
    • 4
  • A. R. Shalita
    • 5
  1. 1.Department of DermatologyNational Institute of HealthBethesdaUSA
  2. 2.Department of DermatologyUniversity of UppsalaUppsalaSweden
  3. 3.Department of DermatologyUniversity Medical Center Steglitz, Free University of BerlinBerlinFR Germany
  4. 4.Leeds Foundation for Dermatological Research Leeds General InfirmaryLeedGreat Britain
  5. 5.Department of DermatologySUNY Health Science CenterBrooklynUSA

Personalised recommendations