Melanoma: Clinical and Therapeutic Aspects

  • E. Macher
  • T. Fitzpatrick
  • H. Rorsman
  • T. B. Fitzpatrick
  • K. Wolff
  • A. R. Rhodes
  • M. C. Mihm
  • A. B. Ackerman
  • W. H. ClarkJr.
  • N. Cascinelli
  • U. R. Kleeberg
  • A. J. Cochran
  • T. Rümke
Conference paper

Abstract

The present-day concept of carcinogenesis includes three stages of development: first, the initiation stage in which a normal cell is affected by a carcinogenic initiator causing genetic damage but leaving the cell phenotypically unaltered: second, a promotion stage in which the genetic damage results in the growth of a visible tumor is essentially benign but has an increased probability for malignant transformation: and, third, the stage of progression during which the tumor infiltrates adjacent tissues and metastasizes.

Keywords

Toxicity Oncol Interferon Cyclophosphamide Indomethacin 

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References

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    Ackerman AB (1985) Malignant melanoma in situ: the flat, curable stage of malignant melanoma. Pathology 17:298–300.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • E. Macher
    • 1
  • T. Fitzpatrick
    • 2
  • H. Rorsman
    • 3
  • T. B. Fitzpatrick
    • 2
  • K. Wolff
    • 4
  • A. R. Rhodes
    • 5
  • M. C. Mihm
    • 6
  • A. B. Ackerman
    • 7
  • W. H. ClarkJr.
    • 8
  • N. Cascinelli
    • 9
  • U. R. Kleeberg
    • 10
  • A. J. Cochran
    • 11
  • T. Rümke
    • 12
  1. 1.Department of DermatologyUniversity of MünsterMünsterFR Germany
  2. 2.Department of DermatologyHarvard Medical School, Massachusetts General HospitalBostonUSA
  3. 3.Department of DermatologyUniversity of LundLasaretteSweden
  4. 4.Department of Dermatology IUniversity of ViennaViennaAustria
  5. 5.Division of DermatologyThe Children’s Hospital, Harvard Medical SchoolBostonUSA
  6. 6.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  7. 7.Department of DermatologyNew York UniversityNew YorkUSA
  8. 8.Department of DermatologyUniversity of PhiladelphiaPhiladelphiaUSA
  9. 9.Department of Surgical OncologyNational Cancer InstituteMilanItaly
  10. 10.HamburgFR Germany
  11. 11.Department of Pathology and SurgeryUniversity of CaliforniaLos AngelesUSA
  12. 12.AmsterdamThe Netherlands

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