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Neoadjuvant Chemotherapy in the Conservative Management of Breast Cancer: A Study of 252 Patients

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Book cover Adjuvant Therapy of Primary Breast Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 115))

Abstract

Concepts concerning breast cancer have been considerably modified during the last 10 years. From the concept of a local disease with secondary metastases, the thinking has changed to that of a two-component disease: local on the one hand, and generalized on the other, the latter being more critical the larger the tumor size, the faster the tumor growth rate, the greater the lymph node involvement, and the less the differentiation on histological or nuclear grading.

Supported by INSERM and C. R. A. C. (Centre de Recherches Appliquées á la Chimiothérapie).

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References

  • Bonadonna G, Valagussa P (1985) Adjuvant systemic therapy for resectable breast cancer. Clin Oncol 3 (2): 259–275

    CAS  Google Scholar 

  • Calle R, Pilleron JP (1979) Radiation therapy for operable breast cancer. 10 years results. Breast 5: 2–6

    Google Scholar 

  • Canellos GP (1984) The treatment of locally advanced breast cancer. Clin Oncol 2 (3): 149–151

    CAS  Google Scholar 

  • Chauvergne J, Durand M, Hoerni B, Cohen P, Lagarde C (1979) La chimiothérapie d’induction dans les cancers du sein à haut risque: Résultats d’une étude thérapeutique prospective. Bull Cancer (Paris) 66: 9–16

    CAS  Google Scholar 

  • Ferguson DJ, Meier P, Karrison J, Dawson PJ, Straus FH, Lowenstein FG (1982) Staging of breast cancer and survival rates. JAMA 248: 1337–1341

    Article  PubMed  CAS  Google Scholar 

  • Fisher B, Redmond C, Eias G, Evans J et al. (1982) Adjuvant chemotherapy of breast cancer: an overview of NSABP findings. Adv Surg Oncol 5: 65–90

    CAS  Google Scholar 

  • Goldie JH, Coldman AJ (1979) A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep 63: 1727–1733

    PubMed  CAS  Google Scholar 

  • Jacquillat C, Baillet F, Auclerc G et al. (1982) Initial chemotherapy and conservative radiotherapy in stage I, II and III breast cancer. Proceedings 13th International Cancer Congress, Seattle, pp 52 (abstract 3218)

    Google Scholar 

  • Jacquillat C, Baillet F, Blondon J et al. (1983) Preliminary results of “neo-adjuvant” chemotherapy in initial management of breast cancer (BC). Proceedings ASCO, San Diego, 112 (abstract C 437)

    Google Scholar 

  • Jacquillat C, Baillet F, Auclerc G et al. (1984a) Cancer du sein: chimiothérapie précédant le traitement loco-régional avec extension des indications du traitement conservateur. Bull Cancer (Paris) 71 (4): 354–360

    CAS  Google Scholar 

  • Jacquillat C, Auclerc G, Baillet F et al. (1984b) Chimiothérapie première dans le cancer du sein: Résultats préliminaires. Ann Med Interne (Paris) 135 4: 1–295

    Google Scholar 

  • Jacquillat C, Weil M, Auclerc G et al. (1985) Neoadjuvant chemotherapy in the conservative management of breast cancer. Study on 205 patients. Proc 1st Int Congress on neoadjuvant chemotherapy. Libbey, Paris

    Google Scholar 

  • Jacquillat C, Baillet F, Weil M et al. (1988) Results of a conservative treatment combining induction (neoadjuvant) and consolidation chemotherapy, hormonotherapy, and external and interstitial irradiation. Cancer 61: 1977–1982

    Article  PubMed  CAS  Google Scholar 

  • Kantarjian HP, Hortobagyi GN, Smith TL, Blumenschein GR, Montague E, Buzdar AU, Martin RG (1984) The management of locally advanced breast cancer, a combined modality approach. Eur J Cancer Clin Oncol 20: 1353–1361

    Article  PubMed  CAS  Google Scholar 

  • Karrer K, Humphreys SR, Goldin A (1967) An experimental model for studying factors which influence metastases of malignant tumors. Int J Cancer 2: 213

    Article  PubMed  CAS  Google Scholar 

  • Nissen-Meyer R, Kjellgren K, Malmio K, Mansson B, Norin T (1978) Surgical adjuvant chemotherapy: results of one short course with cyclophosphamide after mastectomy for breast cancer. Cancer 41: 2088–2098

    Article  PubMed  CAS  Google Scholar 

  • Otmezguine Y, Martin A, Le Bourgeois JP, Maylin C, Raynal M, Sallé M, Pierquin B (1980) Etude des récidives parmi 202 cancéreuses du sein traitées conservativement par radiothérapie. J Eur Radiother 1: 115–130

    Google Scholar 

  • Papaiannou AN (1981) Pre-operative chemotherapy for operable breast cancer. Eur J Cancer 17: 263–269

    Article  Google Scholar 

  • Rubens RD, Seston S, Tong D (1980) Combined chemotherapy and radiotherapy for locally advanced breast cancer. Eur J Cancer 16: 351–356

    Article  PubMed  CAS  Google Scholar 

  • Schabel FM, Griswold DP, Corbett TH, Laster Jr, Dykes DJ, Rose WC (1979) Recent studies with adjuvant chemotherapy or immunotherapy of metastatic solid tumors of mice. In: Jones SE, Salmon SE (eds) Adjuvant therapy of cancer. Grune and Stratton, New York, pp 3–17

    Google Scholar 

  • Tancini G, Bonadonna G, Valagussa P et al. (1983) Adjuvant CM F in breast cancer, comparative 5-year results of 12 versus 6 cycles. J Clin Oncol 1: 1–10

    Google Scholar 

  • Zylberberg B, Salat-Baroux J, Ravina JH, Dormont D, Amiel JP, Dielbold P, Izrael V (1982) Initial chemoimmunotherapy in inflammatory carcinoma of the breast cancer 49: 1537–1543

    CAS  Google Scholar 

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© 1989 Springer-Verlag Berlin · Heidelberg

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Jacquillat, C., Weil, M., Auclerc, G., Auclerc, MF., Khayat, D., Baillet, F. (1989). Neoadjuvant Chemotherapy in the Conservative Management of Breast Cancer: A Study of 252 Patients. In: Senn, HJ., Goldhirsch, A., Gelber, R.D., Osterwalder, B. (eds) Adjuvant Therapy of Primary Breast Cancer. Recent Results in Cancer Research, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83337-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-83337-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83339-7

  • Online ISBN: 978-3-642-83337-3

  • eBook Packages: Springer Book Archive

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