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Chemo- or Endocrine Adjuvant Therapy Alone or Combined in Postmenopausal Patients (GABG Trial 1)

  • W. Jonat
  • M. Kaufmann
  • U. Abel
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 115)

Abstract

The natural history of operable breast cancer can be altered by adjuvant treatment (Lippmann 1986; Salmon 1987). Adjuvant combination chemotherapy (AC), e.g., cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) results in a significant prolongation of disease-free (DFS) and overall survival (OS) in premenopausal node-positive patients. Postmenopausal node-positive patients seem to benefit from endocrine therapy. These data were mainly obtained by overview analysis of randomized trials with treatment groups compared with groups receiving no adjuvant therapy (control) after mastectomy.

Keywords

Breast Cancer Overall Survival Progesterone Receptor Primary Breast Cancer Endocrine Adjuvant Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • W. Jonat
    • 1
  • M. Kaufmann
    • 1
  • U. Abel
    • 1
  1. 1.Abteilung für Gynäkologie und GeburtshilfeUniversitätsklinik HamburgHamburg 20Germany

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