Adjuvant Chemo- and Endocrine Therapy Alone or in Combination in Premenopausal Patients (GABG Trial 1)
The natural history of operable breast cancer can be affected by adjuvant treatment (Lippman 1986; Salmon 1987). Adjuvant combination chemotherapy, e.g., cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) results in a significant prolongation of disease-free (DFS) and overall survival (OS) in premenopausal node-positive patients. These data were mainly obtained by overview analyses of randomized trials with treatment groups as compared with no adjuvant therapy (control) after mastectomy.
KeywordsEstrogen Oncol Bacillus Methotrexate Tamoxifen
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