Monoclonal Antibodies Against Campylobacter pylori
For many years gram-negative bacteria have been found to be attached to human gastric mucosa. S-shaped bacteria were seen closely associated with the surface epithelium, both within and between the gastric pits. The successful culture of these organisms from gastric biopsy material was reported in 1983 by Marshall and Warren . Due to similarities to Campylobacter strains and frequent occurrence in the distal stomach the bacteria were termed Campylobacter pyloridis . However, in 1987 the bacteria were renamed as Campylobacter pylori . The organisms are found almost exclusively in connection with inflammatory changes of the gastric mucosa, and a proposed causal relation between C. pylori, gastritis and ulcer disease is under intense investigation throughout the world. This paper describes monoclonal antibodies for the detection of these bacteria, compared to culture and to another proposed method for rapid detection, namely direct inoculation of urea broth .
KeywordsElectrophoresis Bacillus Glutamine Pseudomonas Catalase
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- 1.Marshall BJ, Warren JR (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet I:1273 –1275Google Scholar
- 2.Anonymous (1985) Validation of publication of new names and new combinations previously effectively published outside the IJSB. Int J Syst Bacteriol 85:223–225Google Scholar
- 6.Påhlson C, Halléń A, Forsum U (1986) Curver rods related to Mobiluncus-phenotypes as defined by monoclonal antibodies. Acta Pathol Microbiol Scand (B) 94:117Google Scholar
- 7.Sternberger LA (1979) Immunocytochemistry. Wiley Medical Publications, John Wiley & Sons, New YorkGoogle Scholar