Abstract
Almost a hundred years ago Pavlov suggested that “alkaline mucus” lining the gastric mucosa neutralized luminal acid (Pavlov 1898). Much later, Hollander postulated that gastric secretion of an alkaline (non-parietal) fluid took place, and that this was produced at a constant rate (see Hollander 1963). He also provided experimental evidence for the occurrence of bicarbonate in the secretion from gastric fundic pouches in dogs after inhibition of the acid secretion by vagotomy and antrectomy. During the last 10 years it has been demonstrated that gastric antral and fundic mucosa in several species, including man, secretes bicarbonate to the lumen by processes which depend on tissue metabolism, and that the secretion can be stimulated and inhibited by a variety of means. Furthermore, the surface epithelium in the duodenum possesses a similarly metabolism-dependent ability to secrete bicarbonate. The rates of secretion are higher in the duodenum than in the stomach and higher in proximal than in more distal segments of the duodenum. In addition, the duodenum shows distinct differences from the stomach with respect both to the processes of the transport of bicarbonate and to the control of the secretion (Flemström and Turnberg 1984; Flemström 1987).
This work was supported by the Swedish Medical Research Council (grant 04X-3515), the Tore Nilsson Foundation and the Medical Research Council of the Academy of Finland.
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© 1988 Springer-Verlag Berlin Heidelberg
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Flemström, G., Knutson, L., Kivilaakso, E. (1988). The Mucus Bicarbonate Barrier and Its Role in Gastroduodenal Mucosal Protection. In: Menge, H., Gregor, M., Tytgat, G.N.J., Marshall, B.J. (eds) Campylobacter pylori. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83322-9_13
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