Advertisement

Current Theories on Pathogenesis of Peptic Ulcer Disease

  • W. Roesch
Conference paper

Abstract

While in the nineteenth century duodenal ulcer was extremely rare and gastric ulcer was essentially a disease of young women, epidemiology changed during the first half of this century, with male predominance and duodenal ulcers leading by about 4:1 (Langman, 1979). Recently there has been a constant decrease, at least in hospital admissions, for peptic ulcer disease, especially in duodenal ulcers, while the complication rates remain constant or even show a considerable increase in older patients, with hemorrhage and perforation, most probably due to consumption of nonsteroidal anti-inflammatory drugs (Wait et al., 1985).

Keywords

Peptic Ulcer Duodenal Ulcer Gastric Ulcer Peptic Ulcer Disease Ulcer Healing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Allen A, Hutton DA, Leonard AJ, Pearson JP, Sellers LA (1986) The role of mucus in the protection of the gastroduodenal mucosa. Scand J Gastroenterol 21 (suppl 125) 71–77CrossRefGoogle Scholar
  2. 2.
    Battaglia G, Farini R, DiMario F, Vianello F, Piccoli A, Plebani M, Naccarato R (1985) Is maximal acid output useful in identifying relapsing duodenal ulcer patients? J Clin Gastroenterol 7:375–378CrossRefPubMedGoogle Scholar
  3. 3.
    Cohen MM, McCready DR, Clark L (1985) Cigarette smoking reduces human gastric luminal prostaglandin E2. Gut 26:1192–1196CrossRefPubMedGoogle Scholar
  4. 4.
    Conn HO, Blitzer BL (1976) Non-association of adrenocorticosteroid therapy and peptic ulcer. New Engl J Med 294:473–479CrossRefPubMedGoogle Scholar
  5. 5.
    Hunt RH, Howden CW, Jones DB, Burget DW, Kerr GD (1986) The correlation between acid suppression and peptic ulcer healing. Scand J Gastroenterol 21 (suppl 125) 22–29CrossRefGoogle Scholar
  6. 6.
    Isenberg JI, Selling JA, Hogan DL, Koss MA (1987) Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. New Engl J Med 316:374–379CrossRefPubMedGoogle Scholar
  7. 7.
    Ippoliti AF (1985) Prognostic factors in ulcer disease: are they real, are they relevant? J Clin Gastroenterol 7:445–446CrossRefPubMedGoogle Scholar
  8. 8.
    Jorde R, Bostad L, Burhol PG (1986) Asymptomatic gastric ulcer: A follow-up study in patients with previous gastric ulcer disease. Lancet 1,119–121CrossRefPubMedGoogle Scholar
  9. 9.
    Kumar N, Kumar A, Broor SL, Vij JC, Anand BS (1986) Effect of milk on patients with duodenal ulcers. Br med J 293:666CrossRefGoogle Scholar
  10. 10.
    Langman MJS (1979) The epidemiology of chronic digestive disease. London, ArnoldGoogle Scholar
  11. 11.
    McLean AJ, Harrison PM, Joannides-Demos L, Byrne AJ, McCarthy P, Dudley FJ (1985) The choice of ulcer healing agent influences duodenal ulcer relapse rate and long-term clinical outcome. Aust NZ J Med 15:367–374CrossRefGoogle Scholar
  12. 12.
    Müler-Lissner SA (1986) Bile reflux is increased in cigarette smokers. Gastroenterology 90:1205–1209Google Scholar
  13. 13.
    Ottenjann R, Bayerdöfer E (1987) Campylobacter pyloridis. Opportunist oder Pathogen im oberen Magen-Darm-Trakt. Dt Äztebl 84:1045–1046Google Scholar
  14. 14.
    Paffenberger RS, Wing AL, Hyde RT (1974) Chronic disease in former college students. Amer J Epidemiol 100:307–315Google Scholar
  15. 15.
    Parente F, Lazzaroni M, Sangaletti O, Baroni S, Bianchi-Porro G (1985) Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients. Gut 26:1327–1332CrossRefPubMedGoogle Scholar
  16. 16.
    Röch W, Kinzler E, Demling L (1973)Das Ulcusrezidiv-Langzeitbeobachtungen. In: Demling L, Moser K, Röch W (eds) Das peptische Ulkus. Pathophysiologic, Diagnose, Therapie. Schattauer, Stuttgart-New YorkGoogle Scholar
  17. 17.
    Scheurer U, Witzel L, Halter F, Keller HM, Huber R, Galeazzi R (1977) Gastric and duodenal ulcer healing under placebo treatment. Gastroenterology, 72:838–841PubMedGoogle Scholar
  18. 18.
    Schwarz K (1910) Uber penetrierende Magen- und Jejunalgeschüre. Bruns Beitr Klin Chir 67:96–128Google Scholar
  19. 19.
    Soil AH (1986) Mechanisms of action of antisecretory drugs. Scand J Gastroenterol (suppl 125)21:1–6CrossRefGoogle Scholar
  20. 20.
    Sonnenberg A (1986) Smoking and mortality from peptic ulcer in the United Kingdom. Gut 27:1369–1372CrossRefPubMedGoogle Scholar
  21. 21.
    Sonnenberg A (1986) Dietary salt is a risk factor in gastric ulcer disease. Gastroenterology 90:1642Google Scholar
  22. 22.
    Wait R, Katschinski B, Logan R, Ashley J, Langman M (1986) Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1:489–491Google Scholar
  23. 23.
    Whitfield PF, Hobsley M (1985) Maximal gastric secretion in smokers and nonsmokers with duodenal ulcer. Brit J Surg 72:955–957CrossRefPubMedGoogle Scholar
  24. 24.
    Wormsley KG (1983) Duodenal ulcer: does pathophysiology equal aetiology? Gut 24:775–780CrossRefPubMedGoogle Scholar
  25. 25.
    Wormsley KG (1986) Ulcer disease: medical treatment. Current Opinion in Gastroenterology 2:855–868CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • W. Roesch

There are no affiliations available

Personalised recommendations