Abstract
While in the nineteenth century duodenal ulcer was extremely rare and gastric ulcer was essentially a disease of young women, epidemiology changed during the first half of this century, with male predominance and duodenal ulcers leading by about 4:1 (Langman, 1979). Recently there has been a constant decrease, at least in hospital admissions, for peptic ulcer disease, especially in duodenal ulcers, while the complication rates remain constant or even show a considerable increase in older patients, with hemorrhage and perforation, most probably due to consumption of nonsteroidal anti-inflammatory drugs (Wait et al., 1985).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allen A, Hutton DA, Leonard AJ, Pearson JP, Sellers LA (1986) The role of mucus in the protection of the gastroduodenal mucosa. Scand J Gastroenterol 21 (suppl 125) 71–77
Battaglia G, Farini R, DiMario F, Vianello F, Piccoli A, Plebani M, Naccarato R (1985) Is maximal acid output useful in identifying relapsing duodenal ulcer patients? J Clin Gastroenterol 7:375–378
Cohen MM, McCready DR, Clark L (1985) Cigarette smoking reduces human gastric luminal prostaglandin E2. Gut 26:1192–1196
Conn HO, Blitzer BL (1976) Non-association of adrenocorticosteroid therapy and peptic ulcer. New Engl J Med 294:473–479
Hunt RH, Howden CW, Jones DB, Burget DW, Kerr GD (1986) The correlation between acid suppression and peptic ulcer healing. Scand J Gastroenterol 21 (suppl 125) 22–29
Isenberg JI, Selling JA, Hogan DL, Koss MA (1987) Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. New Engl J Med 316:374–379
Ippoliti AF (1985) Prognostic factors in ulcer disease: are they real, are they relevant? J Clin Gastroenterol 7:445–446
Jorde R, Bostad L, Burhol PG (1986) Asymptomatic gastric ulcer: A follow-up study in patients with previous gastric ulcer disease. Lancet 1,119–121
Kumar N, Kumar A, Broor SL, Vij JC, Anand BS (1986) Effect of milk on patients with duodenal ulcers. Br med J 293:666
Langman MJS (1979) The epidemiology of chronic digestive disease. London, Arnold
McLean AJ, Harrison PM, Joannides-Demos L, Byrne AJ, McCarthy P, Dudley FJ (1985) The choice of ulcer healing agent influences duodenal ulcer relapse rate and long-term clinical outcome. Aust NZ J Med 15:367–374
Müler-Lissner SA (1986) Bile reflux is increased in cigarette smokers. Gastroenterology 90:1205–1209
Ottenjann R, Bayerdöfer E (1987) Campylobacter pyloridis. Opportunist oder Pathogen im oberen Magen-Darm-Trakt. Dt Äztebl 84:1045–1046
Paffenberger RS, Wing AL, Hyde RT (1974) Chronic disease in former college students. Amer J Epidemiol 100:307–315
Parente F, Lazzaroni M, Sangaletti O, Baroni S, Bianchi-Porro G (1985) Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients. Gut 26:1327–1332
Röch W, Kinzler E, Demling L (1973)Das Ulcusrezidiv-Langzeitbeobachtungen. In: Demling L, Moser K, Röch W (eds) Das peptische Ulkus. Pathophysiologic, Diagnose, Therapie. Schattauer, Stuttgart-New York
Scheurer U, Witzel L, Halter F, Keller HM, Huber R, Galeazzi R (1977) Gastric and duodenal ulcer healing under placebo treatment. Gastroenterology, 72:838–841
Schwarz K (1910) Uber penetrierende Magen- und Jejunalgeschüre. Bruns Beitr Klin Chir 67:96–128
Soil AH (1986) Mechanisms of action of antisecretory drugs. Scand J Gastroenterol (suppl 125)21:1–6
Sonnenberg A (1986) Smoking and mortality from peptic ulcer in the United Kingdom. Gut 27:1369–1372
Sonnenberg A (1986) Dietary salt is a risk factor in gastric ulcer disease. Gastroenterology 90:1642
Wait R, Katschinski B, Logan R, Ashley J, Langman M (1986) Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1:489–491
Whitfield PF, Hobsley M (1985) Maximal gastric secretion in smokers and nonsmokers with duodenal ulcer. Brit J Surg 72:955–957
Wormsley KG (1983) Duodenal ulcer: does pathophysiology equal aetiology? Gut 24:775–780
Wormsley KG (1986) Ulcer disease: medical treatment. Current Opinion in Gastroenterology 2:855–868
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Roesch, W. (1988). Current Theories on Pathogenesis of Peptic Ulcer Disease. In: Menge, H., Gregor, M., Tytgat, G.N.J., Marshall, B.J. (eds) Campylobacter pylori. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83322-9_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-83322-9_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83324-3
Online ISBN: 978-3-642-83322-9
eBook Packages: Springer Book Archive