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Predictive Assays for the Therapy of Rectal Carcinoma

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Combined Modality Therapy of Gastrointestinal Tract Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 110))

Abstract

The decision about the therapeutic treatment of an individual tumor is made on the basis of the localization and the clinical as well as the histopathological staging. However, very different responses to such a treatment are observed for tumors with the same clinical and histopathological stage. From this general clinical expe rience it can be concluded that these tumors differ very much in their individual biological characteristics, which are relevant for the therapeutic response, and more biological data are needed in order to improve the selection of the appropriate therapeutic modality on an individual basis as well as to obtain better prognostic factors [1, 2].

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References

  1. Mitchell JS, Feinendegen LE (1984) Research on the biological individualisation of cancer radiotherapy including the problems of developing countries. Report of meeting of experts, 26–30 April 1982. Strahlentherapie 160: 641–653

    Google Scholar 

  2. Peters LJ, Brock W, Johnson T(1985) Predicting radiocurability. Cancer 55: 2118–2122

    Article  PubMed  CAS  Google Scholar 

  3. Alper T (1979) Cellular radiobiology. Cambridge University Press, Cambridge

    Google Scholar 

  4. Streffer C (1980) Biologische Grundlagen der Strahlentherapie. In: Scherer E (ed) Strahlentherapie. Springer, Berlin Heidelberg New York, pp 197–266

    Google Scholar 

  5. Streffer C, van Beuningen D, Bamberg M, Eigler F-W, Gross E, Schabronath J (1984) An approach to the individualization of cancer therapy. Determination of DNA, SH-groups and micronuclei. Strahlentherapie 160: 661–666

    PubMed  CAS  Google Scholar 

  6. Streffer C, van Beuningen D, Gross E, Schabronath J, Eigler F-W, Rebmann A (1986) Predictive assays for the therapy of rectum carcinoma. Radiother Oncol 5: 303–310

    Article  PubMed  CAS  Google Scholar 

  7. Schmid W (1975) The micronucleus test. Mutat Res 31: 9–15

    PubMed  CAS  Google Scholar 

  8. Heddle JA (1973) A rapid in vivo test for chromosomal damage. Mutat Res 18: 187–198

    Article  PubMed  CAS  Google Scholar 

  9. Midander J, Revesz L (1980) The micronucleus (MN) in irradiated cells as a measure of survival. Br J Cancer 41: 204

    Article  Google Scholar 

  10. Molls M, Streffer C, Zamboglou N (1981) Micronucleus formation in preimplanted mouse embryos cultured in vitro after irradiation with X-rays and neutrons. Int J Radiât Biol 39: 307–314

    Article  CAS  Google Scholar 

  11. van Beuningen D, Streffer C, Bertholdt G (1981) Mikronukleusbildung im Vergleich zur ϋberlebensrate von menschlichen Melanomzellen nach Röntgen-, Neutronenbestrahlung und Hyperthermie. Strahlentherapie 157: 600–606

    PubMed  Google Scholar 

  12. Mlynek M-L, van Beuningen D, Leder L-D, Streffer C (1985) Measurement of the grade of vascularization in histological tumor tissue sections. Br J Cancer 52: 945–948

    Article  PubMed  CAS  Google Scholar 

  13. Tribukait B, Gustafson H (1980) Impulscytophotometrische DNS-Untersuchungen bei Blasenkarzinomen. Onkologie 6: 278–288

    Article  Google Scholar 

  14. Wending P, Manz R, Thews G, Vaupel P (1984) Heterogeneous oxygenation of rectal carcinomas in humans. A critical parameter for preoperative irradiation? Adv Exp Med Biol 180: 293–300

    Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg

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Streffer, C., van Beuningen, D., Mlynek, ML., Gross, E., Eigler, FW. (1988). Predictive Assays for the Therapy of Rectal Carcinoma. In: Schlag, P., Hohenberger, P., Metzger, U. (eds) Combined Modality Therapy of Gastrointestinal Tract Cancer. Recent Results in Cancer Research, vol 110. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83293-2_38

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  • DOI: https://doi.org/10.1007/978-3-642-83293-2_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83295-6

  • Online ISBN: 978-3-642-83293-2

  • eBook Packages: Springer Book Archive

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