Effect of Hyperthermia at 40.5° C and Chemotherapy on Various Human Tumors in Vitro

  • H. A. Neumann
  • H. H. Fiebig
  • R. Engelhardt
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 109)


The possibility of enhancing the effect of cytostatic drugs on tumor cells by means of hyperthermia has been clearly shown by many in vitro and in vivo experiments (Hahn 1982, 1983). In most experiments, experimental cell lines and experimental animal tumors have been used: in only a few have data been obtained using human tumor samples (Mann et al. 1983). With the use of a tumor colony forming assay it is possible to test human tumor samples for their individual drug sensitivity and the possible influence of hyperthermia.


Small Cell Carcinoma Cytostatic Drug Bone Marrow Progenitor Hyperthermic Condition Thermal Enhancement 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H. A. Neumann
    • 1
  • H. H. Fiebig
    • 2
  • R. Engelhardt
    • 2
  1. 1.St. Josef Hospital, Medizinische KlinikRuhr-UniversitätBochumGermany
  2. 2.Medizinische KlinikAlbert-Ludwigs-UniversitätFreiburgGermany

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