Effect of Hyperthermia at 40.5° C and Chemotherapy on Various Human Tumors in Vitro
The possibility of enhancing the effect of cytostatic drugs on tumor cells by means of hyperthermia has been clearly shown by many in vitro and in vivo experiments (Hahn 1982, 1983). In most experiments, experimental cell lines and experimental animal tumors have been used: in only a few have data been obtained using human tumor samples (Mann et al. 1983). With the use of a tumor colony forming assay it is possible to test human tumor samples for their individual drug sensitivity and the possible influence of hyperthermia.
KeywordsDoxorubicin Melphalan Etoposide Vincristine Aqua
Unable to display preview. Download preview PDF.
- Fisher GA, Hahn GM (1982) Enhancement of cis-diaminedichloroplatinum (cis-DDP) cytotoxicity by hyperthermia. Natl Cancer Inst Monogr 61: 255–257Google Scholar
- Hahn GM (1982) Hyperthermia and cancer. Plenum, New YorkGoogle Scholar
- Hahn GM (1983) Hyperthermia to enhance drug delivery. In: Chabner A (ed) Rational basis for chemotherapy UCLA symposia on molecular and cellular biology-new series, vol 4. UCLA symposium on the rational basis for chemotherapy, Keystone, CO, 1982. Liss, New York, pp 427–436Google Scholar
- Hug V, Thames H, Spitzer G, Blumenschein G (1983) Normalization of in vitro sensitivity testing of human tumor progenitor cells. Int J Cell Cloning 1: 257Google Scholar