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Preclinical Hyperthermia pp 149–160Cite as

Thermal Enhancement of the Cell Killing Effect of X-Irradiation in Mammalian Cells in Vitro and in a Transplantable Mouse Tumor: Influence of pH, Thermotolerance, Hypoxia, or Misonidazole

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 109))

Abstract

Many experimental results indicate that the lethal effects of X-irradiation on mammalian cells are the result of damage to DNA. Radiosensitization by hyperthermia, i. e., treatment at temperatures in the range of 42° –47° C, is caused by inhibition of the repair of radiation-induced damage (Bronk 1976). Most of the lethal effects induced by hyperthermia alone are presumably due to damage to other cellular targets, including the plasma membrane and other membrane structures of the cell (Hahn 1982). Both the direct cell-killing effect of hyperthermia and radiosensitization might be exploited in the clinical application of hyperthermia.

Part of the research described here was supported by grants from the KWF (Koningin Wilhelmina Fonds) and from the 1RS (Interuniversitair Instituut voor Radiopathologie en Stralenbescherming).

We thank Mrs. H. Erkelens for the careful typing of the manuscript.

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Authors and Affiliations

  1. Radiotherapy Department, University of Amsterdam, Medical Center (AMC), Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    J. Haveman & J. Wondergem

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  1. J. Haveman
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  2. J. Wondergem
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Editors and Affiliations

  1. Abteilung Strahlentherapie (Med. Klinik) Radiologische Klinik, Albert-Ludwigs-Universität, Hugstetter Straße 55, 7800, Freiburg, Germany

    Wolfgang Hinkelbein , Gregor Bruggmoser , Rupert Engelhardt  & Michael Wannenmacher , ,  & 

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© 1988 Springer-Verlag Berlin Heidelberg

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Haveman, J., Wondergem, J. (1988). Thermal Enhancement of the Cell Killing Effect of X-Irradiation in Mammalian Cells in Vitro and in a Transplantable Mouse Tumor: Influence of pH, Thermotolerance, Hypoxia, or Misonidazole. In: Hinkelbein, W., Bruggmoser, G., Engelhardt, R., Wannenmacher, M. (eds) Preclinical Hyperthermia. Recent Results in Cancer Research, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83263-5_17

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  • DOI: https://doi.org/10.1007/978-3-642-83263-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83265-9

  • Online ISBN: 978-3-642-83263-5

  • eBook Packages: Springer Book Archive

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