Abstract
A biological rationale for treating malignant tumors with hyperthermia has been provided by a great number of studies in recent years. It became obvious that particularly nutritionally deprived, hypoxic and acidic tumor cells were very sensitive to heat (for a review see Dickson and Calderwood 1980; Overgaard and Bichel 1977; Overgaard 1981; Rhee et al. 1984; Song et al. 1980 a; Streffer 1985; Vaupel et al. 1983). This effect was not limited to tumor cells alone, but the deleterious effect of hyperthermia on microscopic blood channels suggested an inverse relationship between blood flow and thermal sensitivity (Dewhirst et al. 1984; Emami and Song 1984; Gullino et al. 1982; Pence and Song 1986; Reinhold and Endrich 1986; Song 1980b). Up to the present, however, only a few studies have evaluated directly the influence of heat on tumor capillaries.
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References
Baez S (1966) Recording of microvascular dimensions with an image-splitter television microscope. J Appl Physiol 21:299–301
Berg-Blok AE, Reinhold HS (1984) Time-temperature relationship for hyperthermia induced stoppage of the microcirculation in tumors. Int J Radiat Oncol Biol Phys 10: 737–740
Dewhirst M, Gross JF, Sim D, Arnold P, Boyer D (1984) The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory flow. Biorheology 21: 539–558
Dickson JA, Calderwood SK (1980) Temperature range and selective sensitivity of tumors to hyperthermia: a critical review. Ann NY Acad Sci 335:180–205
Dudar TE, Jain RK (1984) Differential response of normal and tumor microcirculation to hyperthermia. Cancer Res 44: 605–612
Eddy HA (1980) Alterations in tumor microvasculature during hyperthermia. Radiology 137: 515–521
Emami B, Song CW (1984) Physiological mechanisms in hyperthermia: a review. Int J Radiat Oncol Biol Phys 10: 289–295
Emami B,Nussbaum GH,TenHaken RK,Hughes WL (1980) Physiological effects of hyperthermia: response of capillary blood flow and structure to local tumor heating. Radiology 137: 805–809
Endrich B, Hammersen F (1986)Morphologic and hemodynamic alterations in capillaries during hyperthermia. In: Anghileri LJ, Robert J. (eds) Hyperthermia in cancer treatment, vol 2. CRC, Boca Raton, pp 17–47
Endrich B, Reinhold HS, Gross JF, Intaglietta M (1979 a) Tissue perfusion inhomogeneity during early tumor growth in rats. JNCI 62: 387–395
Endrich B, Zweifach BW, Reinhold HS, Intaglietta M (1979 b) Quantitative studies of microcirculatory function in malignant tissue: influence of temperature on microvascular hemodynamics during the early growth of the BA1112 rat sarcoma. Int J Radiat Oncol Biol Phys 5: 2021–2030
Endrich B,Asaishi K,Götz A,Meßmer K (1980) Technical report. A new chamber technique for microvascular studies in unanesthetized hamsters. Res Exp Med 177:125–134
Endrich B, Götz A, Meßmer K (1982 a) Distribution of microflow and oxygen tension in hamster melanoma. Int J Microcirc Clin Exp 1: 81–99
Endrich B,Hammersen F,Götz A,Meßmer K (1982 b) Microcirculatory blood flow, capillary morphology and local oxygen pressure of the hamster amelanotic melanoma A-Mel-3. JNCI 68: 475–485
Funk W, Endrich B, Meßmer K, Intaglietta M (1983) Spontaneous arteriolar vasomotion as a determinant of peripheral vascular resistance. Int J Microcirc Clin Exp 2:11–25
Gullino PM, Jain RK, Grantham FH (1982) Relationship between temperature and blood supply or consumption of oxygen and glucose by rat mammary carcinomas. JNCI 60: 519–533
Hammersen F, Osterkamp-Baust U, Endrich B (1983) Ein Beitrag zum Feinbau terminaler Strombahnen und ihrer Entstehung in bösartigen Tumoren. Prog Appl Microcirc 2:15–51
Hammersen F, Endrich B, Meßmer K (1985) The fine structure of tumor blood vessels. I. Participation of non-endothelial cells in tumor angiogenesis. Int J Microcirc Clin Exp 4: 31–43
Intaglietta M, Tompkins WR (1973) Microvascular measurements by video image shearing and splitting. Microvasc Res 5: 309–312
Intaglietta M, Pawula RF, Tompkins WR (1970) Pressure measurements in the mammalian microvasculature. Microvasc Res 2: 212–220
Intaglietta M, Silverman NR, Tompkins WR (1975) Capillary flow velocity measurements in vivo and in situ by television method. Microvasc Res 10:165–179
Johnson P (1980)The myogenic response. In: Bohr DF, Somlyo AP, Sparks HV. (eds) Handbook of physiology, vol 2, sect 2. American Physiological Society, Bethesda, pp 409–442
Kessler M, Höper J, Krumme BA (1976) Monitoring of tissue perfusion and cellular function. Anesthesiology 45:184–197
Müller-Klieser W, Vaupel P (1984) Effect of hyperthermia on tumor blood flow. Biorheology 21: 529–538
Oda T, Lehmann A, Endrich B (1984) Capillary blood flow in the amelanotic melanoma of the hamster after isovolemic hemodilution. Biorheology 21: 509–520
Overgaard J (1981) Effect of hyperthermia on the hypoxic fraction in an experimental mammary carcinoma in vivo. Br J Radiol 54: 245–249
Overgaard J, Bichel P (1977) The influence of hypoxia and acidity on the hyperthermic response of malignant cells in vitro. Radiology 123: 511–514
Overgaard J, Nielsen OS (1980) The role of tissue environmental factors on the kinetics and morphology of tumor cells exposed to hyperthermia. Ann NY Acad Sci 335: 254–278
Pence DW, Song CW (1986)Effects of heat on blood flow. In: Anghileri LJ, Robert J. (eds) Hyperthermia in cancer treatment, vol 2. CRC, Boca Raton, pp 1–16
Reinhold HS, Endrich B (1986) Tumour microcirculation as a target for hyperthermia. Int J Hyperthermia 2: 111–137
Reinhold HS, Blachiewicz B, Berg-Blok A (1978)Decrease in tumor microcirculation during hyperthermia. In: Streffer C. (ed) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Munich, pp 231-232
Rhee JG, Kim TH, Levitt SH, Song CW (1984) Changes in acidity of mouse tumor by hyperthermia. Int J Radiat Oncol Biol Phys 10: 393–399
Scheid P (1961) Funktionelle Besonderheiten der Mikrozirkulation im Karzinom. Bibl Anat 1: 327–335
Schmid-Schonbein GW, Zweifach BW, Kovalchek S (1977) The application of stereological principles to morphometry of the microcirculation in different tissues. Microvasc Res 14: 303–317
Song CW, Kang MS, Rhee JG, Levitt SH (1980 a) Effect of hyperthermia on vascular function in normal and neoplastic tissues. Ann NY Acad Sci 335: 35–47
Song CW, Kang MS, Rhee JG, Levitt SH (1980b) The effect of hyperthermia on vascular function, pH and cell survival. Radiology 137: 795–803
Streffer C (1985) Metabolic changes during and after hyperthermia. Int J Hyperthermia 1: 305–319
Vaupel P (1982) Einfluß einer lokalisierten Mikrowellenhyperthermie auf die pH-Verteilung in bosartigen Tumoren. Strahlentherapie 158: 168–173
Vaupel P, Ostheimer K, Müller-Klieser W (1980) Circulatory and metabolic responses of malignant tumors during normothermia and hyperthermia. J Cancer Res Clin Oncol 98: 15–29
Vaupel P, Müller-Klieser W, Otte J, Manz R, Kallinowski F (1983) Blood flow, tissue oxygenation, and pH distribution in malignant tumors upon localized hyperthermia. Basic pathophysiological aspects and the role of various thermal doses. Strahlentherapie 159: 73–81
Von Ardenne M (1986)The present developmental state of cancer multistep therapy (CMT): Selective occlusion of cancer tissue capillaries by combining hyperglycemia with two stage regional or local hyperthermia using the CMT Selectotherm technique. In: Anghileri LJ, Robert J. (eds) Hyperthermia in cancer treatment, vol 3. CRC, Boca Raton, pp 1–24
Wiederhielm CA, Woodbury JW, Kirk ES, Rushmer RF (1964) Pulsatile pressure in the microcirculation of the frog’s mesentery. Am J Physiol 207: 173–176
Wike-Hooley JL, Zee J, Rhoon GC, Berg AP, Reinhold HS (1984) Human tumor pH changes following hyperthermia and radiation therapy. Eur J Cancer Clin Oncol 20: 619–623
Zweifach BW (1974) Quantitative analysis of microcirculatory structure and function. I. Analysis of pressure distribution in the terminal vascular bed in cat mesentery. Circ Res 34: 843–857
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© 1988 Springer-Verlag Berlin · Heidelberg
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Endrich, B., Hammersen, F., Messmer, K. (1988). Hyperthermia-Induced Changes in Tumor Microcirculation. In: Issels, R.D., Wilmanns, W. (eds) Application of Hyperthermia in the Treatment of Cancer. Recent Results in Cancer Research, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83260-4_7
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DOI: https://doi.org/10.1007/978-3-642-83260-4_7
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