Experience with an Annular Phased Array Hyperthermia System in the Treatment of Advanced Recurrences of the Pelvis
Within the last decade hyperthermia (HT) has come more and more into the domain of oncologists. The biological principles of action of heat in the treatment of different malignancies have been presented by many authors, mainly radiobiologists (Bichel et al. 1979; Jorritsma et al. 1985; Overgaard 1978). Not only the synergism of heat and ionizing radiation (Bichel et al. 1979; Jorritsma et al. 1985; Overgaard 1978; Short and Turner 1980; Steindorfer 1985), but also the possible enhancement of the cell-killing effect of different cytotoxic drugs by HT, have been demonstrated within many experimental studies (Dahl 1983; Dahl and Mella 1983; Hahn and Strande 1976; Hahn et al. 1975; Marmor 1969; Mella 1985; Overgaard 1976; Steindorfer 1985). The biologists investigated the effect of so-called moderate HT on normal and tumour tissue in vitro and in vivo. They found that HT between 41.5° C and 45° C had a lot of effects on the tumour cell, depending on exposure time and temperature level (Bichel et al. 1979; Short and Turner 1980; Steindorfer 1985). Metabolism, synthesis of nuclear acids and proteins, cell membranes, cytoskeleton and microsomes are all affected by HT (Steindorfer 1985). The sensitivity of different cells against heat depends on many factors, e.g. pH level of the tissue, oxygen radicals, blood flow rate, cell cycle and previous heat exposure (Short and Turner 1980; Steindorfer 1985). Cells which have been heated before, however long the interval, are able to resist heat for at least 120 h. This particular effect is called “thermotolerance” (TT). The so-called “heat shock proteins” (HSPs) are thought to be responsible for TT (Jorritsma et al. 1985; Li et al. 1982; Muller et al. 1985; Steindorfer 1985).
KeywordsWater Bolus Vital Tumour Cell IEEE Trans Microwave Theory Tech Radiat Oncol Bioi Phys Experimental Cancer Treatment
Unable to display preview. Download preview PDF.
- Gibbs FA (1983) Thermal mapping in experimental cancer treatment with hyperthermia: description and use of a semiautomatic system. Int J Radiat Oncol Biol PhysGoogle Scholar
- Hahn GM, Strande DP (1976) Cytotoxic effects of hyperthermia and adriamycin on Chinese hamster cells. INCI 57: 1063Google Scholar
- Marmor JB (1969) Interactions of hyperthermia and chemotherapy in animals. Cancer Res 39: 2269Google Scholar
- Overgaard J (1978)The effect of local hyperthermia alone, and in combination with radiation, on solid tumors. In: Streffer C, et al. (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Munich, p 49Google Scholar
- Steindorfer P (1985) Hyperthermic und Chemotherapie solider Tumore (Experimentelle Doppelblindstudie an transplantierten 5123-Morris-Hepatomen). Acta Chir Austriaca [Suppl] 63Google Scholar