Abstract
A rapid in vitro assay based on morphological changes in the nucleus has, recently, been reported for predicting human cancer chemosensitivity (Tokita et al. 1986 a, b; Takamizawa et al. 1985). This method provides a realistic potential with regard to the following advantages: (1) We can apply it to any kind of tumors, including intestinal tumors contaminated with bacteria. Consequently, the proportion of tumors yielding sensitivity data is high. (2) The results are obtained within 4 h for alkylating agents and Vinca alkaloids, within 8 h for antibiotic and antimetabolic agents. (3) The assay can be done in a clinical laboratory on a regular basis because of its simplicity.
This study was supported by Bundesministerium für Jugend, Familie, Frauen und Gesundheit, Bonn.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Yamada, K., Neumann, H.A., Fiebig, H.H., Engelhardt, R., Tokita, H. (1988). A Rapid in Vitro Assay for Predicting Thermochemosensitivity of Human Cancer: Comparison with Clonogenic Assay. In: Issels, R.D., Wilmanns, W. (eds) Application of Hyperthermia in the Treatment of Cancer. Recent Results in Cancer Research, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83260-4_25
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DOI: https://doi.org/10.1007/978-3-642-83260-4_25
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