Skip to main content
SpringerLink
Log in

Interaction of Hyperthermia and Chemotherapy

  • Conference paper
Application of Hyperthermia in the Treatment of Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 107))

Abstract

Although hyperthermia alone has limited antitumor effects at clinically tolerable doses, the method is currently being widely studied in combination with radiation, with promising results. A large amount of experimental and clinical data supports this combination. Much less is known about the possibilities of combining hyperthermia and chemotherapeutic drugs. This paper reports experimental data from cell culture and animals. The pharmacological effects of hyperthermia and known mechanisms for the interaction of heat and drugs will be presented. A better understanding of these processes is necessary for rational clinical application of the combined modality approach.

Supported by the Norwegian Cancer Society.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alberts DS, Peng Y-M, Chen GH-S, Moon TE, Cetas TC, Hoescheie JD (1980) Therapeutic synergism of hyperthermia-cis-platinum in a mouse tumor model. JNCI 65: 455–461

    PubMed  CAS  Google Scholar 

  • Arcangeli G, Cividalli A, Lovisolo G, Mauro F, Creton G, Nervi C, Pavin G (1980)Effectiveness of local hyperthermia in association with radiotherapy or chemotherapy: comparison of multimodality treatments on multiple neck node metastases. In: Arcangeli G, Mauro F. (eds) Proceedings of the First Meeting of the European Group of Hyperthermia in Radiation Oncology. Masson Italia, Milano, pp 257–265

    Google Scholar 

  • Arrick BA, Nathan CF (1984) Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer Res 44: 4224–4232

    PubMed  CAS  Google Scholar 

  • Ballard BE (1974) Pharmacokinetics and temperature. J Pharm Sci 63: 1345–1358

    Article  PubMed  CAS  Google Scholar 

  • Barlogie B, Corry PM, Drewinco B (1980) In vitro thermochemotherapy of human colon cancer cells with cis-dichlorodiammineplatinum (II) and mitomycin C. Cancer Res 40: 1165–1168

    PubMed  CAS  Google Scholar 

  • Bates DA, Mackillop WJ (1986) Hyperthermia, adriamycin transport, and cytotoxicity in drug-sensitive and -resistant Chinese hamster ovary cells. Cancer Res 46: 5477–5481

    PubMed  CAS  Google Scholar 

  • Bates DA, Mackillop WJ (1987) Hyperthermia enhances melphalan transport and cytotoxicity in Chinese hamster ovary cells (Abstr). 35th Annual Meeting of the Radiation Research Society, Atlanta

    Google Scholar 

  • Beckley SA, Madajewicz S, Highby D, Takita H, Bhargava A, Wajsman Z, Pontes JE (1982) Combination of systemic hyperthermia with chemotherapy. 13th International Cancer Congress, Seattle

    Google Scholar 

  • Ben-Hur E, Elkind MM (1974) Thermal sensitization of Chinese hamster cells to methyl methanesulfonate: relation of DNA damage and repair to survival response. Cancer Biochem Biophys 1: 23–32

    CAS  Google Scholar 

  • Block JB, Harris PA, Peale A (1975) Preliminary observations on temperature-enhanced drug uptake by leukemic leukocytes in vitro. Cancer Chemother Rep 59: 985–988

    PubMed  CAS  Google Scholar 

  • Braun J, Hahn GM (1975) Enhanced cell killing by bleomycin and 43° hyperthermia and the inhibition of recovery from potentially lethal damage. Cancer Res 35: 2921–2927

    PubMed  CAS  Google Scholar 

  • Bronk BV, Wilkins RJ, Regan JD (1973) Thermal enhancement of DNA damage by an alkylating agent in human cells. Biochem Biophys Res Commun 52: 1064–1070

    Article  PubMed  CAS  Google Scholar 

  • Chapman IV, Leyko W, Gwozdzinski K, Koter M, Grzelinska E, Bartosz G (1983) Hyperthermic modification of bleomycin-DNA interaction detected by electron spin resonance. Radiat Res 96: 518–522

    Article  PubMed  CAS  Google Scholar 

  • Clawson RE, Egorin MJ, Fox BM, Ross LA, Bachur NR (1981) Hyperthermic modification of cyclophosphamide metabolism in rat hepatic microsomes and liver slices. Life Sci 28: 1133–1137

    Article  PubMed  CAS  Google Scholar 

  • Dahl O (1982) Interaction of hyperthermia and doxorubicin on a malignant, neurogenic rat cell line (BT4C) in culture. Natl Cancer Inst Monogr 61: 251–253

    CAS  Google Scholar 

  • Dahl O (1983) Hyperthermic potentiation of doxorubicin and 4’-epi-doxorubicin in a transplantable neurogenic rat tumor (BT4A) in BD IX rats. Int J Radiat Oncol Biol Phys 9: 203–207

    Article  PubMed  CAS  Google Scholar 

  • Dahl O (1986) Hyperthermia and drugs. In: Wathmough DJ, Ross WM. (eds) Hyperthermia. Blackie, Glasgow, pp 121–153

    Google Scholar 

  • Dahl O, Mella O (1982) Enhanced effect of combined hyperthermia and chemotherapy (bleomycin, BCNU) in a neurogenic rat tumour (BT4A) in vivo. Anticancer Res 2: 359–364

    PubMed  CAS  Google Scholar 

  • Dahl O, Mella O (1983) Effect of timing and sequence of hyperthermia and cyclophosphamide on a neurogenic rat tumour (BT4A) in vivo. Cancer 52: 983–998

    Article  PubMed  CAS  Google Scholar 

  • Djordjevic O, Kostic L, Brkic G (1978)The combined effects of hyperthermia and a chemotherapeutic agent on DNA in isolated mammalian cells. In: Streffer C, et al. (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Munich, pp 278–280

    Google Scholar 

  • Dodion P, Riggs CE, Akman SR, Bachur NR (1986) Effect of hyperthermia on the in vitro metabolism of doxorubicin. Cancer Treat Rep 70: 625–629

    PubMed  CAS  Google Scholar 

  • Donaldson SS, Gordon LF, Hahn GM (1978) Protective effect of hyperthermia against the cytotoxicity of actinomycin D on Chinese hamster cells. Cancer Treat Rep 62:1489–1495

    PubMed  CAS  Google Scholar 

  • Douple EB, Strohbehn JW, de Sieyes DC, Alborough DP, Trembly BS (1982) Therapeutic potentiation of cis-dichlorodiammineplatinum (II) and radiation by interstitial microwave hyperthermia in a mouse tumor. Natl Cancer Inst Monogr 61: 259–262

    CAS  Google Scholar 

  • Eksborg S, Ehrsson H (1985) Drug level monitoring: cytostatics. J Chromatogr 340: 31–72

    Article  PubMed  CAS  Google Scholar 

  • Fisher GA, Hahn GM (1982) Enhancement of cis-platinum (II) diamminedichloride cytotoxicity by hyperthermia. Natl Cancer Inst Monogr 61: 255–257

    CAS  Google Scholar 

  • Fujiwara K, Kohno I, Miyao J, Sekiba K (1984)The effect of heat on cell proliferation and the uptake of anti-cancer drugs into tumour. In: Overgaard J. (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 405–408

    Google Scholar 

  • Gerad H, Egorin MJ, Whitacre M, van Echo DA, Aisner J (1983) Renal failure and platinum pharmacokinetics in three patients treated with cis-diamminedichloroplatinum (II) and whole-body hyperthermia. Cancer Chemother Pharmacol 11:162–166

    Article  PubMed  CAS  Google Scholar 

  • Gervasi PG, Agrillo MR, Citti L, Danesi R, del Tacca M (1986) Superoxide anion production by adriamycinol from cardiac sarcosomes and by mitochondrial NADH dehydrogenase. Anticancer Res 6:1231–1236

    PubMed  CAS  Google Scholar 

  • Giovanella BC, Lohman WA, Heidelberger C (1970) Effects of elevated temperatures and drugs on the viability of L1210 leukemia cells. Cancer Res 30:1623–1631

    PubMed  CAS  Google Scholar 

  • Hahn GM (1978)Interactions of drugs and hyperthermia in vitro and in vivo. In: Streffer C, et al. (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Munich, pp 72-79 Hahn GM (1982) Hyperthermia and cancer. Plenum, New York

    Google Scholar 

  • Hahn GM, Shiu EC (1983) Effect of pH and elevated temperatures on the cytotoxicity of some chemotherapeutic agents on Chinese hamster cells in vitro. Cancer Res 43: 5789–5791

    PubMed  CAS  Google Scholar 

  • Hahn GM, Shiu E (1986) Adaption to low pH modifies thermal and thermo-chemical responses of mammalian cells. Int J Hyperthermia 4: 379–387

    Article  Google Scholar 

  • Hahn GM, Strande DP (1976) Cytotoxic effects of hyperthermia and adriamycin on Chinese hamster cells. JNCI 57:1063–1067

    PubMed  CAS  Google Scholar 

  • Har-Kedar I (1975) Effect of hyperthermia and chemotherapy in EMT6 cells. In: Wizenberg MJ, Robinson JE (eds) Proceedings of the International Symposium on Cancer Therapy by Hyperthermia and Radiation. American College of Radiology, pp 91-93

    Google Scholar 

  • Hassanzadeh M, Chapman IV (1982) Thermal enhancement of bleomycin-induced growth delay in a squamous carcinoma of CBA/Ht mouse. Eur J Clin Oncol 18: 795–797

    Article  CAS  Google Scholar 

  • Hecquet B, Meynadler J, Bonneterre J, Adenis L, Demaille A (1985) Time dependency in plasmatic protein binding of cisplatin. Cancer Treat Rep 69: 79–83

    PubMed  CAS  Google Scholar 

  • Herman TC (1983) Effect of temperature an the cytotoxicity of vindesine, amsacrine, and mitoxantrone. Cancer Treat Rep 67:1019–1022

    PubMed  CAS  Google Scholar 

  • Herman TC, Cress AE, Sweets C, Gerner EW (1981) Reversal of resistance to methotrexate by hyperthermia in Chinese hamster ovary cells. Cancer Res 41: 3840–3843

    PubMed  CAS  Google Scholar 

  • Herman TS, Henle KJ, Nagle WA, Moss AJ, Monson TP (1984) Effect of step-down heating on the cytotoxicity of adriamycin, bleomycin, and cis-diamminedichloroplatinum. Cancer Res 44: 1823–1826

    PubMed  CAS  Google Scholar 

  • Honess DJ, Bleehen NM (1980)Effects of the combination of hyperthermia and cytotoxic drugs on the skin of the mouse foot. In: Arcangeli G, Mauro F. (eds) Proceedings of the 1st Meeting of the European Group of Hyperthermia in Radiation Oncology, Masson Italia, Milano, pp 151–155

    Google Scholar 

  • Honess DJ, Bleehen NM (1982) Sensitivity of normal mouse marrow and RIF-1 tumour to hyperthermia combined with cyclophosphamide or BCNU: Lack of therapeutic gain. Br J Cancer 46: 236–248

    Article  PubMed  CAS  Google Scholar 

  • Honess DJ, Bleehen NM (1985) Thermochemotherapy with cisplatinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan only. Br J Cancer 58:63–72

    CAS  Google Scholar 

  • Honess DJ, Donaldson J, Workman P (1985) The effect of systemic hyperthermia on melphalan pharmacokinetics in mice. Br J Cancer 51: 77–84

    Article  PubMed  CAS  Google Scholar 

  • Hromas RA, Andrews PA, Murphy MP, Burns P (1987) Glutathione depletion reverses cisplatin resistance in murine LI210 leukemia cells. Cancer Lett 34: 9–13

    Article  PubMed  CAS  Google Scholar 

  • Issels RD, Bigalow JE, Epstein L, Gerweck LE (1984) Enhancement of cysteamine cytotoxicity by hyperthermia and its modification by catalase and superoxide dismutase in Chinese hamster ovary cells. Cancer Res 44: 3911–3915

    PubMed  CAS  Google Scholar 

  • Johnson HA, Pavelec M (1973) Thermal enhancement of thio-TEPA cytotoxicity. JNCI 50: 903–908

    PubMed  CAS  Google Scholar 

  • Joiner MC, Steel GG, Stephens TC (1982) Response of two mouse tumours to hyperthermia with CCNU or melphalan. Br J Cancer 45: 17–26

    Article  PubMed  CAS  Google Scholar 

  • Kim JH, Kim SH, Alfieri A, Young CW, Silvestrini B (1984) Lonidamine: a hyperthermic sensitizer of HeLa cells in culture and of the Meth-A tumor in vivo. Oncology 41: 30–35

    Article  PubMed  CAS  Google Scholar 

  • Kim YD, Lees DE, Lake CR, Whang-Peng J, Schuette W, Smith R, Bull J (1979) Hyperthermia potentiates doxorubicin-related cardiotoxic effects. JAMA 241:1816–1817

    Article  PubMed  CAS  Google Scholar 

  • Klein ME, Frayer K, Bachur NR (1977) Hyperthermic enhancement of chemotherapeutic agents in LI 210 leukemia. Blood [Suppl] 50: 223

    Google Scholar 

  • Kohno I, Kaneshige E, Fujiwara K, Sekiba K (1978)Thermochemotherapy (TC) for gynecologic malignancies. In: Overgaard J. (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 753–756

    Google Scholar 

  • Kubota Y, Nishimura R, Takai S, Umeda M (1979) Effect of hyperthermia on DNA single-strand breaks induced by bleomycin in HeLa cells. Gann 70: 681–685

    PubMed  CAS  Google Scholar 

  • Kukla L, McGuire WP (1982) Heat-induced recall of bleomycin skin changes. Cancer 50: 2283–2284

    Article  PubMed  CAS  Google Scholar 

  • Lin P-S, Cariani PA, Jones M, Kahn PC (1983) Work in progress: The effect of heat on bleomycin cytotoxicity in vitro and on the accumulation of 57-bleomycin in heat-treated rat tumors. Radiology 146: 213–217

    PubMed  CAS  Google Scholar 

  • Magin RL, Sisik BI, Cysyk RL (1979) Enhancement of bleomycin activity against Lewis lung tumors in mice by local hyperthermia. Cancer Res 39: 3792–3795

    PubMed  CAS  Google Scholar 

  • Magin RL, Cysyk RL, Litterst CL (1980) Distribution of adriamycin in mice under conditions of local hyperthermia which improve systemic drug therapy. Cancer Treat Rep 64: 203–210

    PubMed  CAS  Google Scholar 

  • Marmor JB, Kozak D, Hahn GM (1979) Effects of systemically administered bleomycin or adriamycin with local hyperthermia on primary tumor and lung metastases. Cancer Treat Rep 63: 1279–1290

    PubMed  CAS  Google Scholar 

  • Mella O (1985) Combined hyperthermia and cis-diamminedichloroplatinum in BD IX rats with transplanted BT4A tumours. Int J Hyperthermia 1:171–183

    Article  PubMed  CAS  Google Scholar 

  • Mella O, Dahl O (1985) Timing of combined hyperthermia and l,3-bis-(2-chloroethyl)-l-nitrosourea or cis-diamminedichloroplatin in BD IX rats with BT4A tumours. Anticancer Res 5: 259–264

    PubMed  CAS  Google Scholar 

  • Mella O, Eriksen R, Dahl O, Laerum OD (1987) Acute systemic toxicity of combined cis-diammine-dichloroplatin and hyperthermia in the rat. Eur J Clin Oncol, (in press)

    Google Scholar 

  • Meyn RE, Corry PM, Fletcher SE, Demetriades M (1979) Thermal enhancement of DNA strand breakage in mammalian cells treated with bleomycin. Int J Radiat Oncol Biol Phys 5:1487–1489

    Article  PubMed  CAS  Google Scholar 

  • Meyn RE, Corry PM, Fletcher SE, Demetriades M (1980) Thermal enhancement of DNA damage in mammalian cells treated with cis-diamminedichloroplatinum (II). Cancer Res 40:1136–1139

    PubMed  CAS  Google Scholar 

  • Mimnaugh EG, Waring RW, Sikic BI, Magin RL, Drew R, Litterst CL, Gram TE, Guarino AM (1978) Effect of whole-body hyperthermia on the disposition and metabolism of adriamycin in rabbits. Cancer Res 38:1420–1425

    PubMed  CAS  Google Scholar 

  • Mizuno S, Amagai M, Ishida A (1980) Synergistic cell killing by antitumor agents and hyperthermia in cultured cells. Gann 71: 471–478

    PubMed  CAS  Google Scholar 

  • Morgan JE, Honess DJ, Bleehen NM (1979) The interaction of thermal tolerance with drug cytotoxicity in vitro. Br J Cancer 39: 422–428

    Article  PubMed  CAS  Google Scholar 

  • Murthy MS, Khandekar JD, Travis JD, Scanlon EF (1984)Combined effect of hyperthermia (HT) and platinum compounds in vivo and in vitro on murine and human tumor cells. In: Overgaard J. (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 421–424

    Google Scholar 

  • O’Donnel JF, McKoy WS, MakuchRW, BullJM(1979) Increased in vitro toxicity to mouse bone marrow with l,3-bis(2-chloroethyl)-l-nitrosurea and hyperthermia. Cancer Res 39: 2547–2549

    Google Scholar 

  • Oliverio VT (1973) Toxicology and pharmacology of nitrosourea. Cancer Cemother Rep 4:13–20

    CAS  Google Scholar 

  • Osieka R, Magin RL, Atkinson ER (1978)The effect of hyperthermia on human colon cancer xenografts in nude mice. In: Streffer C, et al. (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Munich, pp 287–290

    Google Scholar 

  • Ostrow S, van Echo D, Egorin M, Witacre M, Grochow L, Aisner J, Colvin M, Bachur N, Wiernik PH (1982) Cyclophosphamide pharmacokinetics in patients receiving whole-body hyperthermia. Natl Cancer Inst Monogr 61: 401–403

    Google Scholar 

  • Overgaard J (1976) Combined adriamycin and hyperthermia treatment of a murine mammary carcinoma in vivo. Cancer Res 36: 3077–3081

    PubMed  CAS  Google Scholar 

  • Reinhold HS, Endrich B (1986) Tumour microcirculation as a target for hyperthermia. Int J Hyperthermia 2:111–137

    Article  PubMed  CAS  Google Scholar 

  • Riviere JE, Page RL, Dewhirst MW, Tyczkowska K, Thrall DE (1986) Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs. Int J Hyperthermia 2: 351–358

    Article  PubMed  CAS  Google Scholar 

  • Rose WC, Veras GH, Laster WR Jr, SchabelFM Jr(1979) Evaluation of whole-body hyperthermia as an adjunct to chemotherapy in murine tumors. Cancer Treat Rep 63:1311–1325

    PubMed  CAS  Google Scholar 

  • Shrieve DC, Li GC, Astromoff A, Harris JW (1986) Cellular glutathione, thermal sensitivity, and thermotolerance in Chinese hamster fibroblasts and their heat-resistant variants. Cancer Res 46: 1684–1687

    PubMed  CAS  Google Scholar 

  • Skibba JL (1982) Effects of hyperthermia on hepatic drug disposition. 13th International Cancer Congress, Seattle

    Google Scholar 

  • Skibba JL, Jones FE, Condon RE (1982) Altered hepatic disposition of doxorubicin in the perfused rat liver at hyperthermic temperatures. Cancer Treat Rep 66:1357–1363

    PubMed  CAS  Google Scholar 

  • Smith PJ, Mircheva J, Bleehen NM (1986) Interaction of bleomycin, hyperthermia and a calmodulin inhibitor (trifluoperazine) in mouse tumour cells. II. DNA damage, repair and chromatin changes. Br J Cancer 53:105–114

    CAS  Google Scholar 

  • Spiro IJ, Denman DL, Dewey WC (1982) Effect of hyperthermia on CHO DNA polymerase a and ß p. Radiat Res 89:134–149

    Article  PubMed  CAS  Google Scholar 

  • Suzuki K (1967) Application of heat to cancer chemotherapy - experimental studies. Nagoya J Med Sci 30:1–21

    PubMed  CAS  Google Scholar 

  • Tacker JR, Anderson RU (1982) Delivery of antitumor drug to bladder cancer by use of phase transition liposomes and hyperthermia. Cancer Res: 1211–1214

    Google Scholar 

  • Teicher BA, Kowal CD, Kennedy KA, Sartorelli AC (1981) Enhancement by hyperthermia of the in vitro cytotoxicity of mitomycin C toward hypoxic tumor cells. Cancer Res 41:1096–1099

    PubMed  CAS  Google Scholar 

  • Twentyman PR, Morgan JE, Donaldson J (1978) Enhancement by hyperthermia of the effect of BCNU against the EMT6 mouse tumor. Cancer Treat Rep 62: 439–443

    PubMed  CAS  Google Scholar 

  • Vaglini M, Andreola S, Attili A, Belli F, Marolda R, Nava M, Prada A, Santinami M, Cascinelli N (1985) Hyperthermic antiblastic perfusion in the treatment of cancer of the extremities. Tumori 71:355–359

    PubMed  CAS  Google Scholar 

  • Van der Linden, Sapareto SA, Corbett TH, Valeriote FA(1984) Adriamycin and heat treatments in vitro and in vivo. In: Overgaard J. (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 449–452

    Google Scholar 

  • Von Szczepanski L, Trott KR (1981) The combined effect of bleomycin and hyperthermia on the adenocarcinoma 284 of the C3H mouse. Eur J Clin Oncol 17: 997–1000

    Article  Google Scholar 

  • Wallach DFH (1977) Basic mechanisms in tumor thermotherapy. J Mol Med 2: 381–403

    CAS  Google Scholar 

  • Wallner KE, DeGregorio MW, Li GC (1986) Hyperthermic potentiation of cis-diamminedichloroplatinum (II) cytotoxicity in Chinese hamster ovary cells resistant to the drug. Cancer Res 46: 6242–6245

    PubMed  CAS  Google Scholar 

  • Wang AL, Tew KD (1985) Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards. Cancer Treat Rep 69: 677–682

    PubMed  CAS  Google Scholar 

  • Wang BS, Lumanglas AL, Ruszala-Mallon V, Wallace RE, Durr FE (1984) Effect of hyperthermia on the sensitivity of human colon carcinoma cells to mitoxanthrone (MX). Proc Am Assoc Cancer Res 25: 341

    CAS  Google Scholar 

  • Warren RD, Bender RA (1977) Drug interactions with antineoplastic agents. Cancer Treat Rep 61: 1231–1241

    PubMed  CAS  Google Scholar 

  • Weinstein JN, Magin RL, Yatvin MB, Zaharko DS (1979) Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors. Science 204:188–191

    Article  PubMed  CAS  Google Scholar 

  • Yamada K, Someya T, Shimada S, Ohara K, Kukita A (1984) Thermochemotherapy for malignant melanoma: combination therapy of ACNU and hyperthermia in mice. J Invest Dermatol 82: 180–184

    Article  PubMed  CAS  Google Scholar 

  • Yamane T, Koga S, Maeta M, Hamazoe R, Karino T, Oda M (1984)Effects of in vitro hyperthermia on concentration of adriamycin in Ehrlich ascites cells. In: Overgaard J (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 409–412

    Google Scholar 

  • Yerushalmi A (1978) Combined treatment of a solid tumour by local hyperthermia and actinomy in D. Br J Cancer 37:827–832

    Article  PubMed  CAS  Google Scholar 

  • Zupi G, Badaracco G, Cavaliere R, Natali PG, Greco C (1984)Influence of sequence on hyperthermia and drug combination. In: Overgaard Je (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 429–432.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oncology, Haukeland Hospital, University of Bergen, 5021, Bergen, Norway

    O. Dahl

Authors
  1. O. Dahl
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik III, Klinikum Großhadern, Ludwig-Maximilians-Universität, Marchioninistraße 15, 8000, München 70, Germany

    Rolf D. Issels  & Wolfgang Wilmanns  & 

  2. Gesellschaft für Strahlen- und Umweltforschung (GSF), Institut für Hämatologie, Landwehrstraße 61, 8000, München 2, Germany

    Rolf D. Issels  & Wolfgang Wilmanns  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Dahl, O. (1988). Interaction of Hyperthermia and Chemotherapy. In: Issels, R.D., Wilmanns, W. (eds) Application of Hyperthermia in the Treatment of Cancer. Recent Results in Cancer Research, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83260-4_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83260-4_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83262-8

  • Online ISBN: 978-3-642-83260-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation