Growth, Cell Proliferation and Morphological Alterations of a Mouse Mammary Carcinoma After Exposure to X-Rays and Hyperthermia
There are numerous studies on the effects of radiation and hyperthermia on experimental animal tumours (Denekamp and Fowler 1977; Hahn 1982). Tumour regression is the criterion of response frequently used in most of these studies. However, a number of biological parameters can influence the effects of radiation and hyperthermic treatment on tumours, and only few of these studies consider simultaneously tumour growth, tumour cell proliferation and morphological alterations (Thomlinson and Craddock 1967; Hermens and Barendsen 1969; Kovacs et al. 1976; Nelson et al. 1976; Rowley et al. 1980). Therefore, it was of interest to study several such parameters on the same tumour system. Metabolic studies were carried out by our group with a C57 mouse mammary carcinoma. The tumours were irradiated with one of various doses of X-rays and heated to 43° C for 30 min following exposure to 10 Gy. Tumour growth, cell proliferation, formation of micronuclei and morphological changes in necrosis and density of small blood vessels were studied.
KeywordsAdenocarcinoma Paraffin Ethidium Rhabdomyosarcoma
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