Abstract
The purpose of this introductory review is to provide a brief summary of some of our recent experimental work in the field of thermal biology that might facilitate the understanding of the biological rationale of combining hyperthermia and radiotherapy in the treatment of cancer. Emphasis is placed on some molecular and cellular aspects of cell killing by heat and of hyperthermic radiosensitization; these appear to be distinct rather than related phenomena.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dertinger H, Jung H (1970) Molecular radiation biology. Springer, Berlin Heidelberg New York
Dewey WC (1983)Hyperthermia in cancer therapy. In: Broerse JJ, Barendsen GW, Kal HB, van der Kogel AG. (eds) Proceedings of the Seventh International Congress of Radiation Research. Martinus Nijhoff, Amsterdam, pp 517–527
Dewey WC, Esch JL (1982) Transient thermal tolerance: cell killing and polymerase activities. Radiat Res 92:611–614
Dewey WC, Hopwood LE, Sapareto SA, Gerweck LE (1977) Cellular responses to combinations of hyperthermia and radiation. Radiology 123: 463–474
Dewey WC, Sapareto SA, Betten DA (1978) Hyperthermic radiosensitization of synchronous Chinese hamster cells: relationship between lethality and chromosomal aberrations. Radiat Res 76: 48–59
Dikomey E, Franzke J (1986) Three classes of DNA strand breaks induced by X-irradiation and internal ß-rays. Int J Radiat Biol 50: 893–908
Dikomey E, Jung H (1987) Correlation between polymerase P activity and thermal radiosensitization in CHO cells. Recent Results Cancer Res (in press)
Dikomey E, Eickhoff J, Jung H (1984) Thermotolerance and thermosensitization in CHO and RIH cells: a comparative study. Int J Radiat Biol 46: 181–192
Dikomey E, Becker W, Wielckens K (1987) Reduction of DNA-polymerase ß activity of CHO cells by single and combined heat treatments. Int J Radiat Biol (in press)
Dube DK, Seal G, Loeb LA (1977) Differential heat sensitivity of mammalian DNA polymerases. Biochem Biophys Res Commun 76: 483–487
Eickhoff J, Dikomey E (1984)Development and decay of acutely induced thermotolerance in CHO cells by different heat shocks at various external pH values. In: Overgaard J. (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 91–94
Gerweck LE, Delaney TF (1984) Persistence of thermotolerance in slowly proliferating plateau phase cells. Radiat Res 97: 365-372 Hahn GM (1982) Hyperthermia and cancer. Plenum, New York
Henle KJ, Leeper DB (1976) Interaction of hyperthermia and radiation in CHO cells: recovery kinetics. Radiat Res 66: 505–518
Henle KJ, Bitner AF, Dethlefsen LA (1979) Induction of thermotolerance by multiple heat fractions in Chinese hamster ovary cells. Cancer Res 39: 2486–2491
Jorritsma JBM, Burgman P, Kampinga HH, Konings AWT (1986) DNA polymerase activity in heat killing and hyperthermic radiosensitization of mammalian cells as observed after fractionated heat treatments. Radiat Res 105: 307–319
Jung H (1986) A generalized concept for cell killing by heat. Radiat Res 106: 56–72
Jung H, Dikomey E, Zywietz F (1986) Ausmaß und zeitliche Entwicklung der Thermoresistenz und deren Einfluß auf die Strahlenempfindlichkeit von soliden Transplantationstumoren. In: Streffer C, Herbst M, Schwabe H. (eds) Lokale Hyperthermic. Deutscher Ärzte-Verlag, Cologne, pp 23–38
Kampinga HH, Jorritsma JBM, Konings AWT (1985) Heat-induced alterations in DNA polymerase activity of HeLa cells and of isolated nuclei. Relation to cell survival. Int J Radiat Biol 47: 29–40
Kamura T, Nielsen OS, Overgaard J (1982) Development of thermotolerance during fractionated hyperthermia in a solid tumor in vivo. Cancer Res 42: 1744–1748
Kellerer AM, Rossi HH(1971) RBE and the primary mechanism of radiation action. Radiat Res 47:15–34
Law MP (1981) The induction of thermal resistance in the ear of the mouse by heating at temperatures ranging from 41.5° C to 45.5° C. Radiat Res 85:126–134
Li GC, Kal HB (1977) Effect of hyperthermia on the radiation response of two mammalian cell lines. Eur J Cancer 13: 65–69
Maher J, Urano M, Rice L, Suit HD (1981) Thermal resistance in a spontaneous murine tumor. Br J Radiol 54:1086–1090
Mills MD, Meyn RE (1983) Hyperthermic potentiation of nonrejoined DNA strand breaks following irradiation. Radiat Res 95: 327–338
Mivechi NF, Dewey WC (1985) DNA polymerase a and ß activities during the cell cycle and their role in heat radiosensitization in Chinese hamster ovary cells. Radiat Res 103: 337–350
Mooibroek J, Zywietz F, Dikomey E, Jung H (1984)Thermotolerance kinetics and growth pattern changes in an experimental rat tumour (RIH) after hyperthermia. In: Overgaard J. (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 215–218
Nielsen OS, Overgaard J (1982) Influence of time and temperature on the kinetics of thermotolerance in L1A2 cells in vitro. Cancer Res 42: 4190–4196
Roti Roti JL, Henle KJ (1980) Comparison of two mathematical models for describing heat-induced cell killing. Radiat Res 81: 374–383
Sciandra J J, Gerweck LE (1986)Thermotolerance in cells. In: Watmough DJ, Ross WM. (eds) Hyperthermia. Blackie, Glasgow, pp 99–120
Spiro IJ, Denman DL, Dewey WC (1982) Effect of hyperthermia on CHO DNA polymerase α and β. Radiat Res 89:134–149
Streffer C (1985) Metabolic changes during and after hyperthermia. Int J Hyperthermia 1: 305–319
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Jung, H., Dikomey, E. (1988). Some Basic Effects in Cellular Thermobiology. In: Issels, R.D., Wilmanns, W. (eds) Application of Hyperthermia in the Treatment of Cancer. Recent Results in Cancer Research, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83260-4_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-83260-4_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83262-8
Online ISBN: 978-3-642-83260-4
eBook Packages: Springer Book Archive