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Minimal Neoplasia pp 94–103Cite as

Incipient Cancer of the Colon: Definition and Histology

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 106))

Abstract

In spite of the fact that we know some pathogenetically significant factors, the etiology of colon carcinoma is basically unknown and this has so far prevented a well-founded concept of prevention. For that reason, all activity in clinical medicine has been directed at the recognition and adequate treatment of the very earliest forms of and preliminary changes in this frequent tumor. The resulting interest, which has now been sustained for decades in formal tumor pathogenesis and its individual steps, is an expression of the fact that in this field all problems are by no means solved. Without doubt, however, in the past decades some progress has been made, not least in the conceptual definition of the carcinoma and its early and preliminary stages.

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References

  • Coffey RJ, Shipley GD, Mores HL (1986) Production of transforming growth factors by human colon cancer lines. Cancer Res 46: 1164–1169

    PubMed  CAS  Google Scholar 

  • Cole JW, McKalen A (1963) Studies on the morphogenesis of adenomatous polyps in the human colon. Cancer 16: 998–1002

    Article  PubMed  CAS  Google Scholar 

  • Day DW, Morson BC (1978) The adenoma-carcinoma sequence. In: Bennington JL (ed) The pathogenesis of colorectal cancer. WB Saunders, Philadelphia, pp 58–71 (Major problems in pathology, vol 10 )

    Google Scholar 

  • Deschner EE (1980) Cell proliferation as a biological marker in human colorectal neoplasia. In: Winawer SJ, Schottenfeld D, Sherlock P (eds) Colorectal cancer: prevention, epidemiology and screening. Raven, New York, pp 133–142

    Google Scholar 

  • Deschner EE (1982) Early proliferative changes in gastrointestinal neoplasia. Am J Gastroenterol 77: 207–211

    PubMed  CAS  Google Scholar 

  • Deschner EE, Maskens AP (1982) Significance of the labelling index and labelling distribution as kinetic parameters in colo-rectal mucosa of cancer patients and DMH-treated animals. Cancer 50: 1136–1141

    Article  PubMed  CAS  Google Scholar 

  • Deschner EE, Lewis CHM, Lipkin M (1963) In vitro study of human rectal epithelial cells. I. Atypical zone of H3-thymidine incorporation in mucosa of multiple polyposis. J Clin Invest 42: 1922–1928

    Article  PubMed  CAS  Google Scholar 

  • De Schryer-Keckemeti K (1986) Large intestine. In: Henson DE, Albores-Saavedra J (eds) The pathology of incipient neoplasia. Saunders, Philadelphia, pp 147–166

    Google Scholar 

  • Fenoglio CM, Kaye IG, Lane N (1973) Distribution of human colonic lymphatics in normal, hyperplastic and adenomatous tissue. Its relationship to metastasis from small carcinomas in pedunculated adenomas, with two case reports. Gastroenterology 64: 51–66

    PubMed  CAS  Google Scholar 

  • Filipe MI (1969) Value of histochemical reactions for mucosubstances in the diagnosis of certain pathological conditions in the colon and rectum. Gut 10: 577–586

    Article  PubMed  CAS  Google Scholar 

  • Filipe MI, Branfoot AC (1974) Abnormal pattern of mucous secretion in apparently normal mucosa of large intestine with carcinoma. Cancer 34: 282–290

    Article  PubMed  CAS  Google Scholar 

  • Franzin G, Scarpa A, Dina R, Zamboni G, Fratton A (1982) “Transitional polyps” of the colon. Endoscopy 14: 174–175

    Google Scholar 

  • Hermanek P, Frühmorgen P, Guggemoos-Holzmann J (1983) The malignant potential of colorectal polyps–a new statistical approach. Endoscopy 15: 16–20

    Article  PubMed  CAS  Google Scholar 

  • Isaacson P, Attwood PRA (1979) Failure to demonstrate the specifity of the morphological and histochemical changes in mucosa adjacent to colonic carcinoma. J Clin Pathol 32: 214–218

    Article  PubMed  CAS  Google Scholar 

  • Lev R, Lane P, Camora P (1985) Mucosa bordering rectosigmoid carcinomas. Hum Pathol 16: 151–161

    Article  PubMed  CAS  Google Scholar 

  • Lipkin M (1977) The identification of individuals at high risk for large bowel cancer. An overview. Cancer 40: 2523–2530

    Article  PubMed  CAS  Google Scholar 

  • Matek W (1985) Die Entwicklung kolorektaler Adenome. In: Bartelheimer H, et al. (eds) Gastroenterologie und Stoffwechsel, Bd 22. Thieme, Stuttgart, p 19

    Google Scholar 

  • Morson BC, Sobin LH (1976) Histological typing of intestinal tumours. In: WHO (ed) Interna-tional histological classification of tumours, no 15. World Health Organization, Geneva, p 56

    Google Scholar 

  • Patzelt V (1936) Der Darm. In: Möllendorf W (ed) Handbuch der mikroskopischen Anatomie des Menschen, vol 5 /3. Springer, Berlin

    Google Scholar 

  • Riddell RH (1984) Dysplasia and cancer in ulcerative colitis: a soluble problem? Scand J Gastroenterol [Suppl 104] 19: 137–149

    Google Scholar 

  • Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, Ahren C, et al. (1983) Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 14: 931–968

    Article  PubMed  CAS  Google Scholar 

  • Schmidbauer G, Heilmann KL (1985) Morphology and histochemistry of the mucosa surrounding small oligotubular adenomas of the large bowel. Pathol Res Pract 180: 45–48

    Article  PubMed  CAS  Google Scholar 

  • Shamsuddin AKM, Trump BF (1981) Colon epithelium. II. In vivo studies of colon carcinogenesis. Light microscopic, histochemical, and ultrastructural studies of histogenesis of azoxymethaneinduced colon carcinomas in Fischer 344 rats. INCI 66: 389–401

    Google Scholar 

  • UICC (1987) TNM Klassifikation der malignen Tumoren 4. Aufl. Hermanek P, Scheibe O, Spiessl B, Wagner G (Hrsg). Springer, Berlin Heidelberg New York London Paris Tokyo

    Google Scholar 

  • Weitz H, Kirscheneder C, Wiebecke B, Eder M (1984) The effect of cholecystectomy on the induc-tion of colorectal tumors in mice by 1,2-dimethylhydrazine. Res Exp Med 184: 59–65

    Article  CAS  Google Scholar 

  • Wiebecke B (1975) Experimentelle Cancerogenese des Magen-Darm-Kanals. B. Darm. In: Grund-mann E (ed) Geschwülste/Tumors III. Springer, Berlin Heidelberg New York, pp 731–767 (Handbuch der allgemeinen Pathologie, vol 6/7)

    Google Scholar 

  • Wiebecke B, Krey U, Löhrs U, Eder M (1973) Morphological and autoradiographic investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchows Arch [A] 360: 179–183

    CAS  Google Scholar 

  • Wiebecke B, Brandts A, Eder M (1974) Epithelial proliferation and morphogenesis of hyperplastic adenomatous and villous polyps of the human colon. Virchows Arch [A] 364: 35–49

    Article  CAS  Google Scholar 

  • Wiebecke B, Brandts A, Eder M (1980) Morphogenesis of hyperplastic polyps and tubular and villous adenomas of the colon with regard of underlying proliferative changes. 17th International Congress of SMIER ( Société Internationale d’Endoscopie et de Ratiocinéma ), Bruxelles 1980

    Google Scholar 

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Author information

Authors and Affiliations

  1. Institut für Pathologie, Universität München, Thalkirchner Straße 36, 8000, München 2, Germany

    B. Wiebecke

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  1. B. Wiebecke
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Editors and Affiliations

  1. Gerhard-Domagk-Institut für Pathologie, Westfälische Wilhelms-Universität Münster, Domagkstraße 17, 4400, Münster, Germany

    Ekkehard Grundmann

  2. Frauenklinik, Medizinische Einrichtungen, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Lutwin Beck

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© 1988 Springer-Verlag Berlin · Heidelberg

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Wiebecke, B. (1988). Incipient Cancer of the Colon: Definition and Histology. In: Grundmann, E., Beck, L. (eds) Minimal Neoplasia. Recent Results in Cancer Research, vol 106. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83245-1_12

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  • DOI: https://doi.org/10.1007/978-3-642-83245-1_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83247-5

  • Online ISBN: 978-3-642-83245-1

  • eBook Packages: Springer Book Archive

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