Suppression and Treatment of EAN by Novel Antiinflammatory Agents Acting on Macrophages
Experimental allergic neuritis (EAN) is an animal model of the acute Guillain-Barré Syndrome. It can be induced in rats by immunization with myelin or the P2 protein. As the pathologic changes progress macrophages become the predominant cell in the nerve and root infiltrates. Electronmicroscopic studies showed that they phagocytose myelin. We initiated the present work in order to examine whether other functional properties of these cells could contribute to the tissue damage. We investigated the effects of antiinflammatory agents with distinct sites of action on the course of the disease.
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