Suppression and Treatment of EAN by Novel Antiinflammatory Agents Acting on Macrophages

  • H. P. Hartung
  • B. Schäfer
  • K. Heininger
  • G. Stoll
  • K. V. Toyka
Part of the Verhandlungen der Deutschen Gesellschaft für Neurologie book series (VDGNEUROLOGIE, volume 4)

Abstract

Experimental allergic neuritis (EAN) is an animal model of the acute Guillain-Barré Syndrome. It can be induced in rats by immunization with myelin or the P2 protein. As the pathologic changes progress macrophages become the predominant cell in the nerve and root infiltrates. Electronmicroscopic studies showed that they phagocytose myelin. We initiated the present work in order to examine whether other functional properties of these cells could contribute to the tissue damage. We investigated the effects of antiinflammatory agents with distinct sites of action on the course of the disease.

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References

  1. 1.
    Heininger K, Stoll G, Linington C, Wekerle H, Toyka KV (1986) Conduction failure and nerve conduction slowing in experimental allergic neuritis induced by P2-specific T-cell lines. Ann Neurol 19: 44–49PubMedCrossRefGoogle Scholar
  2. 2.
    Stoll G, Schwendemann G, Heininger K, Köhne W, Härtung HP, Seit R, Tokya KV (1986) Relation of clinical, serological, morphological, and electrophysiological findings in galactocerebroside-induced experimental allergic neuritis. J Neurol Neurosurg Psychiatr 49: 258–264PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • H. P. Hartung
  • B. Schäfer
  • K. Heininger
  • G. Stoll
  • K. V. Toyka

There are no affiliations available

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