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Hyperthermia in Cancer Therapy: Technical and Clinical Aspects

  • Klaus G. Riedel
Conference paper

Summary

The possibility of significant antitumor activity associated with temperatures over 40° C was first documented by Busch in 1866. Since that time, several investigators have shown that heat alone can cause regression and cure of malignant tumors and that the effect of hyperthermia is related to both duration and level of heat. In recent years a rebirth of interest in hyperthermia was generated by results gained in several medical specialities by combining heat with irradiation and/or chemotherapy. Discussed are techniques for producing hyperthermia with electromagnetic fields. Using these techniques a broad spectrum of malignant tumors can be treated including skin tumors, tumors of the pelvis and thorax, and tumors as small as malignant intraocular neoplasms. Advances in hyperthermic tumor treatment are expected in future generations of ultrasonic and electromagnetic technology, such as improved means for high accuracy of tumor localization and heat delivery. Further work to evaluate thermal toxicity and thermotolerance, as well as sequencing and fractionation of hyperthermic and radiation doses, is indicated to maximize the potential for combined use of these treatment modalities in cancer therapy.

Keywords

Choroidal Melanoma Neovascular Glaucoma High Intensity Ultrasound Microwave Hyperthermia Heat Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

  1. 1.
    Busch, W. (1866): Ober den Einfluß, welchen heftigere Erysipeln zuweilen auf organisierte Neubildungen ausüben. Verl. Naturh. Preuss. Rhein. Westphal. 23: 28–30.Google Scholar
  2. 2.
    Hahn, G.M. (1982): Hyperthermia and cancer. Plenum, Press, New York.Google Scholar
  3. 3.
    Storm, F.K. (1983): Hyperthermia in cancer therapy. G.K. Hall & Co., Boston.Google Scholar
  4. 4.
    Cavaliere, R; Ciocatto, E.C.; Giovanella, B.C.; Margottini, M; Mondovi, B; Moricca, G; Rossi-Fanelli, A. (1967): Selective heat sensitivity of cancer cells. Biochemical and clinical studies. Cancer 20: 1351–1381.CrossRefGoogle Scholar
  5. 5.
    Henle, K.J.; Dethlefsen, L.A. (1980):. Time — temperature relationship for heat-induce& killing of mammalian cells. Ann. NY Acad. Sci. 335: 234–253.CrossRefGoogle Scholar
  6. 6.
    Vaeth, J.M.; Meyer, J. (eds, 1984): Hyperthermia and radiation therapy/chemotherapy in the treatment of cancer. Karger, Basel.Google Scholar
  7. 7.
    Streffer, C. (ed, 1937): Hyperthermia and the therapy of malignant tumors. Recent Results in Cancer Therapy, Vol. 104, Springer, Berlin.Google Scholar
  8. 8.
    Streffer, C.; Van Beuningen, D.; Dietzel, F.; Röttinger, E.; Robinson, E.; Robinson, J.E.; Scherer, E.; Seeber, S.; Trott, K.R. (1978): Cancer therapy by hyperthermia and radiation. Urban & Schwarzenberg, München, Wien, Baltimore.Google Scholar
  9. 9.
    Suit, H.D.; Gerweck, L.E. (1979): Potential for hyperthermia and radiation therapy. Cancer Res. 39: 2290–2298.Google Scholar
  10. 10.
    Ben-Hur, E.; Elkind, M.M.; Bronk, B.V. (1974): Thermally enhanced radio-response of cultured chinese hamster cells: Inhibition of repair of sublethal damage and enhancement of lethal damage. Radiat Res. 58: 38–51.CrossRefGoogle Scholar
  11. 11.
    Li, G.C.; Evans, R.G.; Hahn, G.M. (1976): Modification and inhibition of repair of potentially lethal x-ray damage by hyperthermia. Radiat Res. 67: 491–501.CrossRefGoogle Scholar
  12. 12.
    Bhuyan, B.K.; Day, K.J.; Edgerton, C.E.; Ogunbase, O. (1977): Sensitivity of different cell lines and of different phases in the cell cycle to hyperthermia. Cancer Res. 37: 3780–3784.Google Scholar
  13. 13.
    Song, C.W.; Rhee, J.G.; Levitt, S.H. (1982): Effect of hyperthermia on hypoxic cell fraction in tumor. Int. J. Radiat. Oncol. Biol. Phys. 8: 851–856.Google Scholar
  14. 14.
    Vaupel, P.; Müller-Klieser, W.; Otte, J.; Manz, R.; Kallinowski, F. (1983): Blood flow, tissue oxygenation, and pH-distribution in malignant tumors upon localized hyperthermia. Basic pathophysiological aspects and the role of various thermal doses. Strahlentherapie 159: 73–81.Google Scholar
  15. 15.
    Robinson, J.E.; Wizenberg, M.J.; McCready, W.A. (1974): Radiation and hyperthermia response of normal tissue in situ. Radiology 113: 195.Google Scholar
  16. 16.
    Sciandra, J.J.; Gerweck, L.E. (1986): Thermotolerance in cells. In: Watmough, D.J.; Ross, W. (eds) Hyperthermia — clinical and scientific aspects. Blackie and Son Ltd., Glasgow, pp. 99–120.Google Scholar
  17. 17.
    Bertino, J.R.; Kowal, C.D.; Klein, M.E.; Dombrowski, J.; Mini, E. (1984): The potential for chemotherapy and hyperthermia. In: Vaeth, J.M.; Meyer, J. (eds) Hyperthermia and radiation therapy/chemotherapy in the treatment of cancer. Karger, Basel, pp. 162–170.Google Scholar
  18. 18.
    Engelhardt, R. (1986): Hyperthermia and drugs. In: Streffer, C. (ed) Hyperthermia and the therapy of malignant tumors. Recent Results in Cancer Therapy, Vol. 104, Springer, Berlin, pp. 136–203.Google Scholar
  19. 19.
    Hand, J.W.; Hind, A.J. (1986): A review of microwave and RF applicators for localized hyperthermia. In: Hand, J.W.; James, J.R. (eds) Physical techniques in clinical hyperthermia. Research Studies Press, Letchworth, pp. 98–148.Google Scholar
  20. 20.
    Hand, J.W. (1986): Heat delivery and thermometry in clinical hyperthermia. In: Streffer, C. (ed) Hyperthermia and the therapy of malignant tumors. Recent Results in Cancer Therapy, Vol. 104, Springer, Berlin, pp. 1–23.Google Scholar
  21. 21.
    James, J.R.; Henderson, A; Johnson, R.H. (1986): Compact electromagnetic applicators. In: Hand, J.W.; James, J.R. (eds) Physical techniques in clinical hyperthermia. Research Studies Press, Letchworth, pp. 149–209.Google Scholar
  22. 22.
    Strohbehn, J.W.; Mechling, J.A. (1986): Interstitial techniques for clinical hyperthermia. In: Hand, J.W.; James, J.R. (eds) Physical techniques in clinical hyperthermia. Research Studies Press, Letchworth, pp. 210–287.Google Scholar
  23. 23.
    Brezovich, I.A.; Lilly, hi.B.; Durant, J.R.; Richards, D.B. (1981): A practical system for clinical radiofrequency hyperthermia. Int. J. Radiat. Oncol. Biol. Phys. 7: 432–430.Google Scholar
  24. 24.
    Sapozink, M.D.; Gibbs, F.A.; Egger, M.J.; Stewart, J.R. (1986): Regional hyperthermia for clinically advanced deep-seated pelvic malignancy. Am. J. Clin. Oncol. (CCT) 9: 162–169.CrossRefGoogle Scholar
  25. 25.
    Bruggmoser, G.; Hinkelbein, W.; Engelhardt, R; Wannenmacher, M. (eds) (1986): Locoregional high-frequency hyperthermia and temperature measurement. Recent Results in Cancer Therapy, Vol. 101, Springer, Berlin.Google Scholar
  26. 26.
    Swindell, W. (1986): Ultrasonic hyperthermia. In: Hand, J.W.; James, J.R. (eds) Physical techniques in clinical hyperthermia. Research Studies Press, Letchworth, pp. 288–326.Google Scholar
  27. 27.
    Lommatzsch, P.K. (1983): Beta-irradiation of choroidal melanoma with 106-Ru/ 106-Rh applicators. 16 year’s experience. Arch. Ophthalmol. 101: 713–717.Google Scholar
  28. 28.
    Svitra, P.P.; Finger, P.T.; Packer, S; Paglione, R.; Riedel, K.G.; Albert, D.M. (1984): Microwave hyperthermia for treatment of intraocular tumors. Invest. Ophthalmol. Vis. Sci. 25: 50.Google Scholar
  29. 29.
    Riedel, K.G. (1985): Hyperthermie and Protonenbestrahlung: Ein neuer Wegazur Behandlung des malignen Melanoms im Auge? Habilitationsschrift, LudwigMaximilians-Universität München; published in: Fortschr. Ophthalmol. 83 (1986), 483–488.Google Scholar
  30. 30.
    Riedel, K.G.; Svitra, P.P.; Seddon, J.M.; Albert, D.M.; Gragoudas, E.S.; Koehler, A.M.; Coleman, D.J.; Torpey, J.; Lizzi, F.L.; Driller, J. (1985): Proton beam irradiation and hyperthermia, effects on experimental choroidal melanoma. Arch. Ophthalmol. 103: 1862–1870.Google Scholar
  31. 31.
    Riedel, K.G.; Svitra, P.P.; Seddon, J.M.; Albert, D.M.; Craft, J.L.; Gragou- das, E.S.; Coleman, D.J. (1985): Hyperthermia and irradiation induced changes in experimental choroidal melanoma. Invest. Ophthalmol. Vis. Sci. 26: 37.Google Scholar
  32. 32.
    Svitra, P.P.; Albert, D.M.; Finger, P.T.; Packer, S.; Riedel, K.G.; Soulenas, A.; Paglione, R.; Sang, D. (1986): Evaluation of hyperthermic therapy for human choroidal melanoma in the athymic “nude” mouse model. Invest. Ophthalmol. Vis. Sci. 27: 258.Google Scholar
  33. 33.
    Riedel, K.G.; Schaal, S.T.; Svitra, P.P.; Albert, D.M.; Finger, P.T.; Packer, S. (1987): Ocular changes following combined microwave hyperthermia and beta-irradiation in rabbit eyes. Invest. Ophthalmol. Vis. Sci. 28: 59.Google Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1987

Authors and Affiliations

  • Klaus G. Riedel
    • 1
  1. 1.University Eye Hospital MunichMunich 2Germany

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