The number of substances reported to be capable of directly stimulating aldosterone production from endogenous precursors in autotransplanted or isolated per-fused adrenal glands in vivo or in incubated or superfused adrenal zona glomerulosa cells or tissue in vitro is already amazingly large, but it appears to be constantly increasing. Only agents that could conceivably be of physiological importance as intercellular mediators of aldosterone secretion have been listed in Table 11. Structural analogues of hormones, drugs, toxins, and presumable intracellular mediators are not included. When tested in preparations of dispersed zona glomerulosa cells, most of these agents elicited dose-dependent significant increments of aldosterone production in physiological concentrations. In incubated intact zona glomerulosa tissue preparations, some stimulators, in particular peptide hormones such as angiotensin II or ACTH, displayed their steroidogenic activity only at relatively high concentrations, often far above the physiological range. Other substances, such as catecholamines, stimulated aldosterone production only when tested in a system of previously cultured zona glomerulosa cells or tissue (De Léan et al. 1984c; Pratt et al. 1985). There are also obvious species differences. Thus, serotonin, a potent stimulator of steroidogenesis in rat quartered adrenals (Müller and Ziegler 1968) and zona glomerulosa cells (Haning et al. 1970), was completely inactive in sheep adrenocortical tissue (McDougall et al. 1976).
KeywordsDopamine Cortisol Prostaglandin Glucocorticoid Androgen
pro-opiomelanocortin (biological precursor protein of ACTH and β-lipotropin)
“aldosterone-stimulating factor” (isolated from human urine)
Unable to display preview. Download preview PDF.