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Membrane glycoproteins of endothelial cells and platelets

  • J. A. van Mourik
  • J. C. Giltay
  • O. C. Leeksma
  • J. Zandbergen-Spaargaren
Conference paper
Part of the Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften book series (HD AKAD, volume 1987/88 / 1987/4)

Abstract

Considerable evidence now supports an active role for vascular endothelial cells in the initiation and control of various physiological and pathophysiological processes including hemostasis, thrombosis, inflammation and immunological processes. Several events associated with these processes occur at the endothelial cell plasma membrane level. For instance, endothelial cells may assemble coagulation factors at their surface and, upon appropriate stimulation, possess the capacity to provide a catalytic surface for the coagulation cascade (Stern et al. 1985, Bevilacqua et al. 1986). Similarly, endothelial cells bind leukocytes when they are exposed to appropriate stimuli such as endotoxin or interleukin-1 (Bevilacqua et al. 1985, Schleimer and Rutledge 1986). Thus, certain endothelial cell membrane constituents, either constitutively expressed or exposed at the outer plasma membrane surface upon induction, serve as mediators of these processes.

Keywords

Vascular Endothelial Cell Plasma Membrane Protein Platelet Glycoprotein Bovine Endothelial Cell Recombinant Tumor Necrosis Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. A. van Mourik
    • 1
  • J. C. Giltay
    • 1
  • O. C. Leeksma
    • 1
  • J. Zandbergen-Spaargaren
    • 1
  1. 1.Central Laboratory of the Netherlands Red Cross Blood Transfusion ServiceAmsterdamThe Netherlands

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