Membrane glycoproteins of endothelial cells and platelets
Considerable evidence now supports an active role for vascular endothelial cells in the initiation and control of various physiological and pathophysiological processes including hemostasis, thrombosis, inflammation and immunological processes. Several events associated with these processes occur at the endothelial cell plasma membrane level. For instance, endothelial cells may assemble coagulation factors at their surface and, upon appropriate stimulation, possess the capacity to provide a catalytic surface for the coagulation cascade (Stern et al. 1985, Bevilacqua et al. 1986). Similarly, endothelial cells bind leukocytes when they are exposed to appropriate stimuli such as endotoxin or interleukin-1 (Bevilacqua et al. 1985, Schleimer and Rutledge 1986). Thus, certain endothelial cell membrane constituents, either constitutively expressed or exposed at the outer plasma membrane surface upon induction, serve as mediators of these processes.
KeywordsElectrophoresis Fibrinogen Glyco Diester
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