Leukotriene C metabolizing enzymes
The leukotrienes are a group of biologically active compounds, formed by lipoxygenase catalyzed activation of certain polyunsaturated fatty acids (e.g. arachidonic acid) to allylic epoxy acids. This reaction is followed by enzymatic hydrolysis of the epoxy group to give LTB4 or by conjugation with glutathione to give LTC4. The products of these transformations (LTB4 and LTC4) act as mediators of inflammation and immediate hypersensitivity reactions. This is a short summary of the currently available information regarding the enzymes involved in LTC4 metabolism.
KeywordsArachidonic Acid Epoxy Group Broad Substrate Specificity Glutathione Transferase Mercapturic Acid
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