Leukotriene C metabolizing enzymes

  • Lars Örning
  • Kerstin Bernström
  • Mats Söderström
  • Bengt Mannervik
  • Sven Hammarström
Conference paper
Part of the Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften book series (HD AKAD, volume 1987/88 / 1987/4)

Abstract

The leukotrienes are a group of biologically active compounds, formed by lipoxygenase catalyzed activation of certain polyunsaturated fatty acids (e.g. arachidonic acid) to allylic epoxy acids. This reaction is followed by enzymatic hydrolysis of the epoxy group to give LTB4 or by conjugation with glutathione to give LTC4. The products of these transformations (LTB4 and LTC4) act as mediators of inflammation and immediate hypersensitivity reactions. This is a short summary of the currently available information regarding the enzymes involved in LTC4 metabolism.

Keywords

Hydrolysis Leukemia Glutathione Epoxy Glycine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Lars Örning
    • 1
  • Kerstin Bernström
    • 1
  • Mats Söderström
    • 2
  • Bengt Mannervik
    • 2
  • Sven Hammarström
    • 1
  1. 1.Department of Physiological ChemistryKarolinska InstitutetStockholmSweden
  2. 2.Department of Biochemistry, Arrhenius LaboratoryUniversity of StockholmStockholmSweden

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