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Endogenous Cysteinyl Leukotrienes as Mediators in Endotoxin Shock and Tissue Trauma

  • D. Keppler
  • W. Hagmann
  • C. Denzlinger
  • S. Rapp
  • M. Huber
  • A. Guhlmann
  • S. Kästner
Conference paper
Part of the Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften book series (HD AKAD, volume 1987/88 / 1987/4)

Abstract

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are mediators of in flammatory and anaphylactic reactions (Samuelson 1983, Hammarström 1983). Injection of cysteinyl leukotrienes into sensitive species causes shock-like reactions, myocardial depression (Lefer 1986, Feuerstein 1984), and widespread extravasation of plasma (Hua et al.1985). Many of these pathophysiologic signs are also observed after endotoxin administration, and direct evidence for a key role of cysteinyl leukotrienes as mediators in endotoxin shock has been presented recently (Hagmann et al. 1984,1985,1986). An involvement of leukotrienes as mediators in tissue trauma is not only indicated by pharmacological antagonism but also by demonstration of systemic leukotriene production after surgical or thermal trauma in the anesthetized rat (Denzlinger et al. 1985). A key to the understanding of the role of cysteinyl leukotrienes in pathophysiological and physiological processes is the elucidation of their metabolism in vivo (Hammarström 1983, Hagmann et al. 1984,1985,1986, Keppler et al. 1985,1987, Denzlinger et al. 1985, 1986, Huber et al. 1987), and the determination of their concentrations under pathophysiological conditions in vivo (Hagmann et al. 1984,1985,1986, Denzlinger et al. 1985,1986, Keppler et ai. 1985,1987).

Keywords

Acute Pancreatitis Tissue Trauma Endotoxin Shock Toxin Lethality Endotoxin Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • D. Keppler
    • 1
  • W. Hagmann
    • 1
  • C. Denzlinger
    • 1
  • S. Rapp
    • 1
  • M. Huber
    • 1
  • A. Guhlmann
    • 1
  • S. Kästner
    • 1
  1. 1.Biochemisches InstitutUniversität Freiburg im BreisgauFreiburgGermany

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