Abstract
There is increasing evidence that macrophages play an important role in the pathogenesis of the atherogenic process. These cells take up and degrade cholesterol either by phagocytosis of whole cells and membrane fragments or by receptor-mediated endocytosis of cholesterol-containing lipoproteins. After lysosomal degradation of the cholesteryl esters which is mediated by the enzyme acid cholesteryl ester hydrolase (ACEH) the liberated cholesterol is released from the cells. When macrophages take up more lipoprotein cholesterol than they can excrete, cholesterol is stored in the cytoplasm in the form of cholesteryl ester droplets, leading to the formation of foam cells.
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Literature
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© 1987 Springer-Verlag Berlin Heidelberg
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Schmitz, G., Robenek, H. (1987). The Role of HDL in Cholesterol Homeostasis of Macrophages and Reversed Cholesterol Transport. In: Schettler, G. (eds) Molecular Biology of the Arterial Wall. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1987/88 / 1987/4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83118-8_3
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DOI: https://doi.org/10.1007/978-3-642-83118-8_3
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