The Motor of Leukocytes and Platelets: 1986
Arterial wall injury is believed to involve, among other factors, the interaction of platelets and leukocytes with endothelial cells. Shape changes and movements including spreading, locomotion and secretion (platelets and leukocytes) and rounding (endothelial cells) originate in a motor in the cortical cytoplasm. This is the domain of the actin cytoskeleton. Actin regulated by actin-binding proteins and signal molecules may produce mechanical effects that account for the cell functions described.
KeywordsActin Filament Actin Network Actin Monomer Actin Assembly Cortical Cytoplasm
- Chaponnier, C, Yin HL, Stossel TP (1986) Reversible interaction between gelsolin and actin in macrophages. J Exp Med, in press.Google Scholar
- Dingus, J, Hwo, CS, Bryan, J (1986) Identification by monoclonal antibodies and characterization of human platelet caldesmon. J Cell Biol 102Google Scholar
- Hartwig, JH, Shevlin, P (1986) Architecture of actin filaments in the peripheral cytoplasm of lung macrophages and the ultrastructural localization of actin-binding protein. J Cell Biol, in press.Google Scholar
- Kwiatkowski, DJ, Stossel, TP, Colten, HR, Mole, JE, Orkin, SH, Yin, HL (1986). Plasma and cytoplasmic gelsolins contain repeated domains and are encoded by a single gene. Nature, in press.Google Scholar