The Motor of Leukocytes and Platelets: 1986

  • Thomas P. Stossel
  • John H. Hartwig
  • Paul A. Janmey
  • Helen L. Yin
  • Ken S. Zaner
Conference paper
Part of the Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften book series (HD AKAD, volume 1987/88 / 1987/4)

Abstract

Arterial wall injury is believed to involve, among other factors, the interaction of platelets and leukocytes with endothelial cells. Shape changes and movements including spreading, locomotion and secretion (platelets and leukocytes) and rounding (endothelial cells) originate in a motor in the cortical cytoplasm. This is the domain of the actin cytoskeleton. Actin regulated by actin-binding proteins and signal molecules may produce mechanical effects that account for the cell functions described.

Keywords

Hydrolysis Inositol Phorbol 

References

  1. Chaponnier, C, Yin HL, Stossel TP (1986) Reversible interaction between gelsolin and actin in macrophages. J Exp Med, in press.Google Scholar
  2. Dingus, J, Hwo, CS, Bryan, J (1986) Identification by monoclonal antibodies and characterization of human platelet caldesmon. J Cell Biol 102Google Scholar
  3. Hartwig, JH, Shevlin, P (1986) Architecture of actin filaments in the peripheral cytoplasm of lung macrophages and the ultrastructural localization of actin-binding protein. J Cell Biol, in press.Google Scholar
  4. Janmey, PA, Peetermarns, J, Zaner, KS, Stossel, TP, Tanaka, T (1986) Structure and mobility of actin filaments as measured by quasielastic light scattering, visometry, and electron microscoy. J Biol Chem 261: 8357–8362.PubMedGoogle Scholar
  5. Kwiatkowski, DJ, Stossel, TP, Colten, HR, Mole, JE, Orkin, SH, Yin, HL (1986). Plasma and cytoplasmic gelsolins contain repeated domains and are encoded by a single gene. Nature, in press.Google Scholar
  6. Lassing, I, Lindberg, U (1985). Specific interaction between phosphatidyl inositol 4,5, phosphate and profilactin. Nature 314: 472–473.PubMedCrossRefGoogle Scholar
  7. Sha’afi, RI, Shefcyk, J, Yassin, R, Molski, TFP, Naccache, PH, White, JR, Feinstein, MB, Becker, EL (1986). Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal actin? J Cell Biol 102: 1459–1463.PubMedCrossRefGoogle Scholar
  8. Stossel, TP, Chaponnier, C, Ezzell, RM, Hartwig, JH, Janmey, PA, Kwiatkwoski, DJ, Lind, SE, Southwick, FS, Yin, HL, Zaner, KS (1985). Nonmuscle actin-binding proteins. Ann Rev Cell Biol 1: 353–402.PubMedCrossRefGoogle Scholar
  9. Trotter, JA, Nixon, CS, Johnson, MA (1985). The heavy chain of macrophage myosin is phosphorylated at the tip of the tail. J Biol Chem 260: 14374–14378.PubMedGoogle Scholar
  10. Zaner KS (1986) The effect of the 540-kilodalton actin cross-linking protein, actin-binding protein, on the mechanical properties of F-actin. J Biol Chem 261: 7615–7620.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Thomas P. Stossel
    • 1
  • John H. Hartwig
    • 1
  • Paul A. Janmey
    • 1
  • Helen L. Yin
    • 1
  • Ken S. Zaner
    • 1
  1. 1.Hematology/Oncology UnitMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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