The Participation of Oxygen Free Radicals in Septic Shock
The pathophysiology of septic shock is complex and still remains unsolved. The high incidence of septic shock is related to the increasing numbers of elderly, malnourished or immuno-incompetent patients undergoing invasive diagnostic and therapeutic procedures. The source of sepsis is mainly the respiratory, gastrointestinal and urogenital tract. Septic shock in patients leads initially to hyper-dynamic changes of the circulation. In a later stage of disease, patients develop a hypodynamic type of shock and/or multiple organ failure. The trigger for these severe and often deleterious circulatory alterations and organ damages is endotoxin, a lipopolysaccharid liberated mainly from gram-negative bacteria. Already during the hyperdynamic phase of septic shock, high concentrations of circulating endotoxin are frequently observed .
KeywordsSeptic Shock Xanthine Oxidase Oxygen Free Radical Disseminate Intravascular Coagulation Arachidonic Acid Metabolism
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