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Septic Shock pp 108-115 | Cite as

The Participation of Oxygen Free Radicals in Septic Shock

  • M. H. Schoenberg
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 4)

Abstract

The pathophysiology of septic shock is complex and still remains unsolved. The high incidence of septic shock is related to the increasing numbers of elderly, malnourished or immuno-incompetent patients undergoing invasive diagnostic and therapeutic procedures. The source of sepsis is mainly the respiratory, gastrointestinal and urogenital tract. Septic shock in patients leads initially to hyper-dynamic changes of the circulation. In a later stage of disease, patients develop a hypodynamic type of shock and/or multiple organ failure. The trigger for these severe and often deleterious circulatory alterations and organ damages is endotoxin, a lipopolysaccharid liberated mainly from gram-negative bacteria. Already during the hyperdynamic phase of septic shock, high concentrations of circulating endotoxin are frequently observed [1].

Keywords

Septic Shock Xanthine Oxidase Oxygen Free Radical Disseminate Intravascular Coagulation Arachidonic Acid Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. H. Schoenberg

There are no affiliations available

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