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Microcirculatory Changes in Endotoxinemia and Septic Shock

  • Conference paper
Septic Shock

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 4))

Abstract

In contrast to longstanding beliefs, septic shock in man starts as a rule with a hyperdynamic circulatory state as first described by Waisbren [1] and only in a later phase, turns into the hypodynamic type of shock. During recent years, adequate experimental models of septicemia and endotoxin shock have been developed, e.g. models in which protracted induction of systemic endotoxinemia results in a hyperdynamic circulatory state [2]. From recent experimental, but also from clinical studies, it is apparent that the lung is the first target among all organs for the endotoxins liberated from the pathogenic bacteria. Hyperventilation, tachycardia, fever, hypotension, thrombocytopenia and leukocytopenia are the symptoms heralding imminent severe septicemia.

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Authors
  1. K. Messmer
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Free University Hospital, De Boelelaan 1117, NL-1081 HV, Amsterdam, The Netherlands

    Jean Louis Vincent (Assistant-Director) & Lambertus G. Thijs (Assistant-Director) & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Messmer, K. (1987). Microcirculatory Changes in Endotoxinemia and Septic Shock. In: Vincent, J.L., Thijs, L.G. (eds) Septic Shock. Update in Intensive Care and Emergency Medicine, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83108-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-83108-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17861-3

  • Online ISBN: 978-3-642-83108-9

  • eBook Packages: Springer Book Archive

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