Abstract
Septic shock is a convenient clinical term used to describe a condition in which severe hemodynamic instability is attributable principally or wholly to infection. Although bacteria are clearly involved in this process, interpretation of their role has changed in recent years, and it is now generally accepted that host defence and environmental factors also exert a major influence on the development of the syndrome. This chapter presents a clinical appraisal of the microbiological aspects of septic shock in the context of general intensive care, with special reference to patients suffering from surgical complications or major trauma. No attempt is made to discuss laboratory aspects.
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Levison ME, Pontzer RE (1985) In: Mandell GL, Douglas RG, Bennett JE (eds) Principles and Practice of Infectious Diseases 2nd ed. Wiley Medical, New York, p 480
Machiedo GW, Loverme PJ, McGovern PJ, Blackwood JM (1981) Patterns of mortality in a surgical Intensive Care Unit. Surg Gynecol Obstet 152: 757–759
Ledingham IMcA, McArdle CS (1978) Prospective study of the treatment of septic shock. Lancet 2: 1194–1197
Blaisdell FW (1981) Controversy in Shock Research. Con: The role of steroids in septic shock. Circ Shock 8: 673–82
Kerr JA (1979) Current topics in tetanus. Intensive Care Med 5: 105–110
Heimbach RD, Boerema I, Brummelkamp WSH, Wolfe WG (1977) Current therapy of gas gangrene. In: Davis JC, Hunt TK (eds) Hyperbaric Oxygen Therapy. Bethesda: Undersea Medical Society 153–176
Ledingham IMcA, Tehrani MA (1975) Diagnosis, clinical course and treatment of acute dermal gangrene. Br J Surg 62: 364–372
Thomas D, Withington PS (1985) Toxic shock syndrome: A review of the literature. Ann Roy Coll Surg Eng 67: 156–158
Guiliano A, Lewis F, Hadley K, Blaisdell FW (1977) Bacteriology of necrotizing fasciitis. Am J Surg 134: 52–57
Shepherd JH (1982) The toxic shock syndrome. Br J Hosp Med 28: 234–246
Miller RM, Polakavetz SH, Hornick RB, Cowley RA (1973) Analysis of infections acquired by the severely injured patient. Surg Gynecol Obstet 137: 7–10
Thorp JM, Richards WC, Telfer ABM (1979) A survey of infection in an Intensive Care Unit. Anaesthesia 34: 643–650
Ledingham IMcA, Bradley JA, McCartney C, Redding PJ (1983) Infection and Septic Shock. In: Bain WH, Taylor KM (eds) Handbook of Intensive Care. John Wright, Bristol, pp 196–237
Van Saene HKF, Stoutenbeek CP, Miranda DR, Zandstra DF (1983) A novel approach to infection control in the Intensive Care Unit. Acta Anaesth Belg 34: 193–208
Schimff SC, Miller RM, Polakavetz RN, Hornick RB (1974) Infection in the severely traumatised patient. Ann Surg 179: 352–357
Braun SR, Levin AB, Clark KL (1986) Role of corticosteroids in the development of pneumonia in mechanically ventilated head-trauma victims. Crit Care Med 14: 198–201
Laforce FM (1981) Hospital-acquired gram-negative rod pneumonias: An overview. Am J Med 70: 664–669
Wolff SM (1982) The treatment of gram-negative bacteremia and shock. N Engl J Med 307: 1267–1268
Gransden WR, Eykyn SJ, Phillips I (1984) Staphylococcus aureus bacteraemia: 400 episodes in St. Thomas’s hospital. Br Med J 288: 300–303
Gransden WR, Eykyn SJ, Phillips I (1985) Pneumococcal bacteraemia: 325 episodes diagnosed at St. Thomas’s Hospital. Br Med J 290: 505–508
Kreger BE, Craven DE, McCabe WR (1980) Gram-negative bacteremia IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med 68: 344–355
Meakins JL, Wicklund B, Forse RA, McLean APH (1980) The surgical Intensive Care Unit; Current concepts in infection. Surg Clin N Am 60: 117–132
Wiles JB, Cerra FB, Siegel JH, Border JR (1980) The systemic septic response: does the organism matter? Crit Care Med 8: 55–60
Cerra FB (1982) Metabolic implications of human sepsis. In: Polk (ed) Infection and the surgical patient. Clinical Surgery International Vol 4. Churchill Livingstone, Edinburgh, pp 181–96
Simmons RL, Solomkin JS (1982) The host. In: Polk (ed) Infection and the surgical patient. Clinical Surgery International Vol 4. Churchill Livingstone, Edinburgh, pp 3–18
Mclrvine AJ, Mannick JA (1983) Lymphocyte function in the critically ill surgical patient. Surg Clin N Am (Critical Illness) 63: 245–261 (Pt 2)
Tietschel ET, Wollenweber HW, Zähringer U, Luderitz O (1982) Lipid A, the lipid component of bacterial lipopolysaccharides: Relation of chemical structure to biological activity. Klin Wochenschr 60: 705–709.
McCartney AC, Banks JG, Clements GB, Sleigh JD, Tehrani M, Ledingham IMcA (1983) Endotoxaemia in septic shock: clinical and post mortem correlations. Intensive Care Med 9: 117–122
Piotrowicz BI, Edlin SE, McCartney AC (1985) A sensitive chromogenic Limulus amoebocyte lysate micro-assay for detection of endotoxin in human plasma and in water. Zbl Bakt Hyg A 260: 108–112
Stoutenbeek CHP, Van Saene HKF, Miranda DR, Waay D, Zandstra DF (1984) The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients. Intensive Care Med 10: 185–192
Ledingham IMcA, Alcock SR, McDonald JC, Ramsay G, Eastaway A, Mackay I (1987) Selective parenteral and enteral antisepsis regimen (SPEAR) in the Intensive Therapy Unit (in preparation)
Ledingham IMcA, McDonald JC, Alcock SR (1987) The adult respiratory distress syndrome and selective decontamination of the digestive tract (submitted)
Montgomery AB, Stager MA, Carrico J, Hudson LD (1985) Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Resp Dis 132: 485–89
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Ledingham, I.M., Alcock, S.R., Bradley, J.A. (1987). Microbiological Aspects of Septic Shock. In: Vincent, J.L., Thijs, L.G. (eds) Septic Shock. Update in Intensive Care and Emergency Medicine, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83108-9_18
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DOI: https://doi.org/10.1007/978-3-642-83108-9_18
Publisher Name: Springer, Berlin, Heidelberg
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