Abstract
The precise pathophysiology of septic shock is yet unknown, as is the number and the relative importance of the various mediators that are believed to initiate and maintain the syndrome. This is mainly due to the lack of adequate animal shock models [1] and the unavoidable inhomogeneity of the groups of patients studied [2]. Nonetheless, the enormous volume of research that has been performed in this field, particularly in the last decades, makes it possible today to trace more reliable hypotheses on the pathogenesis of septic shock, with particular emphasis on cellular and subcellular structures and functions.
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References
Weil MH (1977) Current understanding of mechanisms and treatment of circulatory shock caused by bacterial infections. Ann Clin Res 9: 181–190
Cerra FB, Hasset J, Siegel JH (1978) Vasodilator therapy in clinical sepsis with low output syndrome. J Surg Res 25: 180–187
Chaudry IH, Baue AE (1982) Overview of hemorragic shock. In: Cowley RA, Trump BF (eds) Pathophysiology of shock, anoxia and ischemia. Williams and Wilkins, Baltimore London, pp 203–219
George RJD, Tinker J (1983) The pathophysiology of shock. In: Tinker J, Rapin M (eds) Care of the critically ill patient. Springer, Berlin Heidelberg New York Tokyo, pp 163–187
Novelli GP (1986) Oxygen radicals in the pathogenesis of circulatory shock. In: Gasparetto A (ed) International Resuscitation Days–Excerpta Medica, International Congress Series N° 699 pp 83–99
Trump BF, Berezesky IK, Cowley RA (1982) The cellular and subcellular characteristics of acute and chronic injury with emphasis on the role of calcium. In: Cowley RA, Trump BF (eds) Pathophysiology of shock, anoxia and ischemia. Williams and Wilkins, Baltimore London, pp 6–46
Kilpatrick-Smith L, Erecinska M, Silver IA (1981) Early cellular responses in vitro to endotoxin administration. Circ Shock 8: 585–600
Montanari G, Corbucci GG, Gasparetto A (1979) Cellular shock. In: Gasparetto A, Novelli GP. Aspetti bioumorali dello shock. Minerva Medica, Torino pp 43–56
Carafoli E, Crompton M (1976) Calcium ions and mitochondria. Soc Exp Biol Symp 30: 89–115
Schumer W, Erve PR (1975) Cellular metabolism in shock. Circ Shock 2: 109–127
Brigham KL (1984) Interactions of granulocytes with the lung. Circ Res 50: 623–635
Harlan JM (1985) Leukocyte-endothelial cell interactions. Blood 65: 513–525
Harlan JM (1983) Effects of lipopolysaccharide on human endothelial cells in culture. Thromb Res 29: 15–16
Brigham KL, Meyrick B (1986) Endotoxin and lung injury. Am Rev Respir Dis 133: 913–927
Keller GA, West MA, Cerra FB, et al (1985) Modulation of hepatocyte protein synthesis by endotoxin activated Kuppfer cells. Ann Surg 131: 87–95
Di Luzio AR, Grafton CG (1970) A consideration of the role of the RES in endotoxin shock. Adv Exp Med Biol 9: 27–35
Cowley RA, Hankins JR, Jones RT, Trump BF (1982) Pathology and pathophysiology of the liver. In: Cowley RA, Trump BF (eds) Pathophysiology of shock, anoxia and ischemia. Williams and Wilkins, Baltimore London, pp 285–301
Mela L, Bacalzo LV, Miller LD (1971) Defective oxidative metabolism of rat liver mitochondria in hemorragic and endotoxic shot. Am J Physiol 220: 571–579
Lefer AM (1986) Thromboxanes and leukotrienes as mediators of ischemia and shock. In: Gasparetto A (ed) International Resuscitation Days–International Congress series N° 699 pp 59–76
Wardle N (1979) Bacteriemic and endotoxic shock. Br J Hosp Med 23: 223–231
Glenn TM, Lefer AM, Beardsley AC, et al (1972) Circulatory responses to splanchnic lysozomal hydrolases in the dog. Ann Surg 176: 120–127
Nagler AL, Levenson SM (1975) The role of humoral factors in shock. In: Ledingham I McA (ed) Shock: Clinical and experimental aspects–Excerpta Medica Amsterdam, pp 79–109
Ogletree M, Oates J, Brigham K, Hubbard W (1982) Evidence for pulmonary release of 5-hydroxyeicosatetraenoic acid (5-HETE) during endotoxemia in sheep. Prostaglandins Leukotrienes Med 8: 489–502
Manson HH, Deardoff MB, Eaton LR (1986) Possible role of leukocyte-derived oxygen free radicals in the myocardial failure of sepsis. In: Novelli GP, Ursini F (eds) Oxygen free radicals in shock. Karger, Basel, pp 165–169
Schayer RW (1962) Evidence that induced histamine is an intrinsic regulator of the micro-circulatory system. Am J Physiol 202: 66–72
Holaday JW, Bernton EW, Kinney RC, Long JB, Malcom DS (1986) Endogenous opioids in shock, spinal trauma and stroke. In: Gasparetto A (ed) International Resuscitation Days–Excerpta Medica. International Congress Series N° 699, pp 45–58
Demopulos B, Flamm ES (1981) Possible pathology induced by CoQ15. In: Folkers K, Yamamura Y (eds) Biomedical and clinical aspects of coenzyme Q. Elsevier–Holland Biomedical Press, pp 373–380
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Crimi, G., Antonelli, M., De Blasi, R.A. (1987). Cell Metabolic Failure in Septic Shock. In: Vincent, J.L., Thijs, L.G. (eds) Septic Shock. Update in Intensive Care and Emergency Medicine, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83108-9_1
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DOI: https://doi.org/10.1007/978-3-642-83108-9_1
Publisher Name: Springer, Berlin, Heidelberg
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