• H. Rodney Withers
  • Jean-Claude Horiot
Part of the Medical Radiology book series (MEDRAD)


Clinical and experimental evidence suggests that, as an overall strategy, radiotherapy for most cancers should be given using the smallest practical dose per fraction and the shortest overall treatment duration. Any attempt to modify standard fractionation patterns to use smaller dose fractions and or a shorter overall time will require more than 5 fractions per week. However, the fact that both strategies result in 2 or more treatments on some or every treatment day should not obscure the different biological reasons for adopting them. Shortening the overall treatment time (accelerated fractionation) aims to minimize the effect of regeneration of tumor clonogens during treatment while the use of small dose fractions (hyperfractionation) is aimed at exploiting differences in the radio-biology of the tumor and late responding normal tissues. Hyperfractionation is the use of dose fractions smaller than standard. Accelerated fractionation is a shortening of the overall duration of a fractionated dose regimen. (Hyperfractionated accelerated treatment involves both a reduced dose per fraction and a shorter overall time.)


Tumor Control Rate Late Sequela Supraglottic Larynx Accelerate Fractionation Field Reduction 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H. Rodney Withers
    • 1
  • Jean-Claude Horiot
    • 2
  1. 1.University of CaliforniaLos AngelesUSA
  2. 2.Centre Georges-Francois-LeclercDijonFrance

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