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Photodynamic Therapy

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Innovations in Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The use of light absorbing chemicals to cause photoreactions in biological systems dates back to at least 1900 when Raab reported a lethal effect on paramecium exposed to light and an acridine dye. Since that time numerous examples of the “photodynamic effect” have been reported for a wide range of photosensitizers both in vitro and in vivo (for a review see Spikes and Straight 1967). In most cases oxygen is required in addition to a photosensitizer and light. The mechanism generally accepted for inactivation of biological systems is an energy transfer process from the excited triplet state of the sensitizer to oxygen, producing singlet oxygen which causes irreversible oxidation of some essential cellular component.

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Authors and Affiliations

  1. Roswell Park Memorial Institute, Buffalo, NY, 14263, USA

    Thomas J. Dougherty Ph.D.

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  1. Thomas J. Dougherty Ph.D.
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Editors and Affiliations

  1. Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, 90024, Los Angeles, CA, USA

    H. Rodney Withers M.D., D.Sc. (Director, Professor) (Director, Professor)

  2. Division of Radiotherapy, The University of Texas M.D. Anderson Hospital and Tumor Institute, 77030, Houston, TX, USA

    Lester J. Peters M.D. (Professor and Head) (Professor and Head)

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© 1988 Springer-Verlag Berlin Heidelberg

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Dougherty, T.J. (1988). Photodynamic Therapy. In: Withers, H.R., Peters, L.J. (eds) Innovations in Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83101-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-83101-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83103-4

  • Online ISBN: 978-3-642-83101-0

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