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Innovations in Radiation Oncology pp 143–153Cite as

Intraoperative Radiotherapy

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Intraoperative radiotherapy (IORT) is an area of renewed clinical interest in the treatment of locally advanced tumors of the abdomen, pelvis and retroperitoneum. The strategy of IORT is quite simple. It involves the use of a large dose of radiation delivered, at the time of surgical exploration, to a tumor or tumor bed and potential areas of locoregional spread. The use of IORT may improve the therapeutic ratio of tumor control to normal tissue toxicity for two major reasons. First, the extent of tumor can be more precisely defined at surgery and directly irradiated. Second, all or part of sensitive normal tissues or organs may be exeluded from the treatment volume by operative mobilization, customized lead shielding, and/or the selection of appropriate electron beam energies. In theory, these are definite advantages compared to conventional external beam irradiation where the tumor (or target) volume can be difficult to define, even with contrast CT scanning, and where the total radiation dose is often limited by the tolerance of adjacent normal tissues incidentally incorporated within the external beam treatment volume.

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Author information

Authors and Affiliations

  1. National Institutes of Health, Building 10, Bethesda, MD, 20892, USA

    Timothy J. Kinsella M.D., William F. Sindelar M.D. Ph.D. & Zelig Tochner M.D.

  2. Massachusetts General Hospital, Boston, MA, 02114, USA

    Joel E. Tepper M.D. (Associate Professor)

  3. 6723 Bertner Avenue, Houston, TX, 77030, USA

    Tyvin A. Rich M.D. (Assistant Professor)

Authors
  1. Timothy J. Kinsella M.D.
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  2. William F. Sindelar M.D. Ph.D.
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  3. Zelig Tochner M.D.
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  4. Joel E. Tepper M.D.
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  5. Tyvin A. Rich M.D.
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Editor information

Editors and Affiliations

  1. Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, 90024, Los Angeles, CA, USA

    H. Rodney Withers M.D., D.Sc. (Director, Professor) (Director, Professor)

  2. Division of Radiotherapy, The University of Texas M.D. Anderson Hospital and Tumor Institute, 77030, Houston, TX, USA

    Lester J. Peters M.D. (Professor and Head) (Professor and Head)

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© 1988 Springer-Verlag Berlin Heidelberg

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Kinsella, T.J., Sindelar, W.F., Tochner, Z., Tepper, J.E., Rich, T.A. (1988). Intraoperative Radiotherapy. In: Withers, H.R., Peters, L.J. (eds) Innovations in Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83101-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-83101-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83103-4

  • Online ISBN: 978-3-642-83101-0

  • eBook Packages: Springer Book Archive

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