Coagulation Factor Deficiencies with Tendency to Thrombosis

  • Fritz Reinhard Matthias


Antithrombin III is formed in the liver. It inhibits first of all factor II a (thrombin) and factor Xa. In addition factors VIIa, IXa, XIa, XIIa, plasmin and kallikrein are inhibited. The plasma concentration is between 14 mg and 20 mg/100 ml of plasma, or between 80 and 120% of the norm. The biological half-life is 2.8 ° 0.3 days. A drop in antithrombin III to 70–80% of the norm is accompanied by an increased tendency to thrombosis. Antithrombin III deficiency may be congenital or acquired (Table 1).


Acute Liver Failure Disseminate Intravascular Coagulation Coumarin Derivative Heparin Therapy Consumption Coagulopathy 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Fritz Reinhard Matthias
    • 1
  1. 1.Department of Internal MedicineJustus Liebig-UniversityGießenFederal Republic of Germany

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