Coagulation Factor Deficiencies with Tendency to Thrombosis
Antithrombin III is formed in the liver. It inhibits first of all factor II a (thrombin) and factor Xa. In addition factors VIIa, IXa, XIa, XIIa, plasmin and kallikrein are inhibited. The plasma concentration is between 14 mg and 20 mg/100 ml of plasma, or between 80 and 120% of the norm. The biological half-life is 2.8 ° 0.3 days. A drop in antithrombin III to 70–80% of the norm is accompanied by an increased tendency to thrombosis. Antithrombin III deficiency may be congenital or acquired (Table 1).
KeywordsAcute Liver Failure Disseminate Intravascular Coagulation Coumarin Derivative Heparin Therapy Consumption Coagulopathy
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