Coagulation Factor Deficiencies with Tendency to Thrombosis
Antithrombin III is formed in the liver. It inhibits first of all factor II a (thrombin) and factor Xa. In addition factors VIIa, IXa, XIa, XIIa, plasmin and kallikrein are inhibited. The plasma concentration is between 14 mg and 20 mg/100 ml of plasma, or between 80 and 120% of the norm. The biological half-life is 2.8 ° 0.3 days. A drop in antithrombin III to 70–80% of the norm is accompanied by an increased tendency to thrombosis. Antithrombin III deficiency may be congenital or acquired (Table 1).
KeywordsEstrogen Heparin Serine Thrombin Fibrinogen
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