Physiology of Blood Coagulation and Hemostasis

  • Fritz Reinhard Matthias

Abstract

The function of hemostasis and of the fibrinolytic systems is the maintenance of the fluidity of the vascular contents and of the integrity of the vessel wall. After local injury of the vascular system the extravasation of blood is stopped by the formation of a hemostatic plug, and after thrombosis a dissolution with total or partial reconstitution of the affected vascular section is attained through the fibrinolytic system. In these processes, vessel wall and vessel contents stand in close interrelationship. The coagulation and fibrinolysis are to be understood as dynamic processes. Many findings support the view that in the blood a constant turnover of coagulatory and fibrinolytic proteins as well as their inhibitors occurs. A physiologically latent coagulation is opposed by a physiologically latent fibrinolysis. Additional conditions are an adequate perfusion of the vascular system and an intact clearance of activated coagulation and fibrinolysis products in the reticuloendothelial system (RES). The processes described are linked to the presence of sufficient and functionally competent hemostasis and fibrinolysis potentials.

Keywords

Heparin Adenosine Serotonin Lysine Glutamine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barnhart MI, Chen ST (1978) Vessel wall models for studying interaction capabilities with blood platelets. Sem Thrombos Hemostas 5: 112PubMedGoogle Scholar
  2. Clouse LH, Comp PC (1986) The regulation of hemostasis: the protein C system. N Engl J Med 314: 1298PubMedCrossRefGoogle Scholar
  3. Collen D (1980) On the regulations and control of fibrinolysis. Edward Kowalski memorial lecture. Thrombos Haemostas 43: 77Google Scholar
  4. Goldsmith HL, Yu SSK, Marlow J (1975) Fluid mechanical stress and the platelet. Thromb Diath Haemorrh 34: 32-41PubMedGoogle Scholar
  5. Griffin JH, Cochrane CG (1979) Recent advances in the understanding of contact activation reactions. Sem Thrombos Hemostas 5: 254PubMedGoogle Scholar
  6. Griffin JH (1981) The contact phase of blood coagulation. In: Bloom AL, Thomas DP (eds) Haemostasis and Thrombosis. Churchill Livingstone Edinburgh, London, Melbourne and New York, p 84Google Scholar
  7. Henry RL (1977) Platelet function. Sem Thrombos Hemostas 4: 93PubMedGoogle Scholar
  8. Holmsen H (1977) Prostaglandin endoperoxides-thromboxane synthesis and dense granule secretion as positive feedback loops in the propagation of platelet responses during “The Basic Platelet Reaction”. Thrombos Haemostas 38: 1030Google Scholar
  9. Kaplan AP, Meier HL, Mandle jr R (1976) The Hageman factor dependent pathways of coagulation, fibrinolysis and kinin generation. Sem Thrombos Hemostas 3: 1PubMedGoogle Scholar
  10. Kopeć M, Latallo ZS (1978) Fibrinogen and fibrin degradation products. In: Markwardt F (Hrsg) Fibrinolytic and Antifibrinolytics, P. Springer, Berlin Heidelberg New York, p 81Google Scholar
  11. Schmid-Schönbein H (1977) Microrheology of erythrocytes and thrombocytes, blood viscosity and the distribution of blood flow in the microcirculation. In: Meesen H (Hrsg) Handbuch der Allgemeinen Pathologie. Springer, Berlin Heidelberg New York, S 289Google Scholar
  12. Vargaftig BB, Chignard M, Le Couedic JP, Benveniste J (1980) One, two, three or more pathways for platelet aggregation. Acta Med Scand (Suppl) 642: 23Google Scholar
  13. Vargaftig B, Chignard BM, Benveniste J (1981) Present concepts on the mechanisms of platelet aggregation. Biochem Pharmacol 30: 263PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Fritz Reinhard Matthias
    • 1
  1. 1.Department of Internal MedicineJustus Liebig-UniversityGießenFederal Republic of Germany

Personalised recommendations