Physiology of Blood Coagulation and Hemostasis
The function of hemostasis and of the fibrinolytic systems is the maintenance of the fluidity of the vascular contents and of the integrity of the vessel wall. After local injury of the vascular system the extravasation of blood is stopped by the formation of a hemostatic plug, and after thrombosis a dissolution with total or partial reconstitution of the affected vascular section is attained through the fibrinolytic system. In these processes, vessel wall and vessel contents stand in close interrelationship. The coagulation and fibrinolysis are to be understood as dynamic processes. Many findings support the view that in the blood a constant turnover of coagulatory and fibrinolytic proteins as well as their inhibitors occurs. A physiologically latent coagulation is opposed by a physiologically latent fibrinolysis. Additional conditions are an adequate perfusion of the vascular system and an intact clearance of activated coagulation and fibrinolysis products in the reticuloendothelial system (RES). The processes described are linked to the presence of sufficient and functionally competent hemostasis and fibrinolysis potentials.
KeywordsHeparin Adenosine Serotonin Lysine Glutamine
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