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Predisposing Factors and Host Defense Response to Sepsis and Septic Shock

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Sepsis

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Abstract

Despite great advances in all aspects of surgery and intensive care, infection remains an incompletely resolved problem. Although data vary, about 30% of hospital surgical deaths have an infectious process. In intensive care areas with critically ill surgical patients, the infection rate is even higher, and the incidence of a life-threatening septic picture with organ failure is about 30%. The historical infections of the nineteenth century are now controlled, as are those of the preantibiotic era, via many approaches. However, if further progress is to be made in the control of morbidity and mortality from infection, the biology of sepsis must be examined and areas suitable for treatment approaches defined. It is only in the context of a biologic approach to sepsis that host defenses or resistance to infection can be seen to offer a real therapeutic approach with great potential for the future [1, 23].

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Authors
  1. J. L. Meakins
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Editors and Affiliations

  1. Klinik für Anästhesiologie und operative Intensivmedizin, Freie Universität Berlin, Universitätsklinikum Steglitz, Hindenburgdamm 30, 1000, Berlin 45, Germany

    K. Reinhart  & K. Eyrich  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Meakins, J.L. (1989). Predisposing Factors and Host Defense Response to Sepsis and Septic Shock. In: Reinhart, K., Eyrich, K. (eds) Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83083-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-83083-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83085-3

  • Online ISBN: 978-3-642-83083-9

  • eBook Packages: Springer Book Archive

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