Sepsis pp 298-306 | Cite as

Clinical Relevance of Endotoxin and Eicosanoids in Severe Sepsis

  • W. Oettinger
  • D. Berger
  • H. G. Beger


Severe sepsis is understood as a syndrome leading to menacing impairment of vital organ functions secondary to infection. Its most pronounced form is septic shock, which is presently defined by hemodynamic and objective functional data from various organ systems. Severe sepsis results primarily from the invasion of mostly gram-negative germs. Its biological effector is identified as endotoxin, in particular, its toxic component lipid A [1], both located in the bacterial wall. Most threatening, therefore, are all contaminations of large body areas or dense bacterial growth of endotoxincontaining germs such as Escherichia coli, Klebsiella, Pseudomonas, Proteus, and Pyocyaneus.


Septic Shock Severe Sepsis Endotoxin Shock Shock Phasis Aseptic Surgery 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • W. Oettinger
  • D. Berger
  • H. G. Beger

There are no affiliations available

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