Abstract
Sepsis and septic shock are very common syndromes, occurring in virtually all fields of medicine. Septic shock is the major cause of death in intensive care units, and its occurrence carries a mortality rate of approximately 60%. The incidence of sepsis has been increasing in recent years due to the increasing use of invasive medical devices, aggressive use of chemotherapy, and increasing survival of patients who are predisposed to sepsis.
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References
Weil MH, MacLean LD, Visscher MB, Spink WW (1956) Studies on the circulatory changes in the dog produced by endotoxin from gram-negative microorganisms. J Clin Invest 35: 1191–1198
Nishijima H, Weil MH, Shubin H, Cavanilles J (1973) Hemodynamic and metabolic studies on shock associated with gram-negative bacteremia. Medicine 52: 287–294
Wilson RF, Thal AP, Kindling PH, Grifka T, Ackerman E (1965) Hemodynamic measurements in septic shock. Arch Surg 91: 121–129
Winslow EJ, Loeb HS, Rahimtoola SH, Kamath S, Gunnar RM (1973) Hemodynamic studies and results of therapy in 50 patients with bacteremic shock. Am J Med 54: 421–432
Weisel RD, Vito L, Dennis RC, Valerie CR, Hechtman HB (1977) Myocardial depression during sepsis. Am J Surg 133: 512–521
Wiles JB, Cerra EB, Siegel JR, Border JR (1980) The systemic septic response: does the organism matter? Crit Care Med 8: 55–60
MacLean LD, Mulligan WG, McLean APH, Duff JH (1967) Patterns of septic shock in man–a detailed study of 56 patients. Ann Surg 166: 543–562
Parker MM, Shelhamer JH, Bachrach SL, et al. (1984) Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100: 483–490
Parker MM, Shelhamer JH, Natanson C, Alling DW, Parrillo JE (1987) Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis. Crit Care Med 15: 923–929
Calvin JE, Driedger AA, Sibbald WJ (1981) An assessment of myocardial function in human sepsis utilizing ECG gated cardiac scintigraphy. Chest 38: 579–586
Ellrodt AG, Riedinger MS, Kimchi A, et al. (1985) Left ventricular performance in septic shock: reversible segmental and global abnormalities. Am Heart J 110: 402–408
Kimchi A, Ellrodt AG, Berman S, et al. (1984) Right heart ventricular performance in septic shock: a combined radionuclide and hemodynamic study. J Am Coll Cardiol 4: 945–951
Ozier Y, Gueret P, Jordin F, et al. (1984) Two-dimensional echocardiographic demonstration of acute myocardial depression in septic shock. Crit Care Med 12: 596–599
Parker MM, Suffredini AF, Natanson C, et al. (1986) Survivors of septic shock in humans develop reversible myocardial depression and ventricular dilatation. Clin Res 34: 413A (Abstract)
Natanson C, Fink MP, Ballantyne HK, et al. (1986) Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J Clin Invest 78: 259–275
Natanson C, Danner RL, Fink MP, et al. (1988) Cardiovascular performance with E. coli challenges in a canine model of human septic shock. Am J Physiol 23: H558 - H569
Suffredini AF, Parker MM, Brenner M, Schlesinger T, Parrillo JE (1987) Endotoxin (E) administration produces abnormal cardiovascular ( CV) responses in normal humans. Clin Res 35: 386A (Abstract)
Hinshaw LB, Archer LT, Spitzer JJ, et al. (1974) Effects of coronary hypotension and endotoxin on myocardial performance. Am J Physiol 227: 1051–1057
Lefer AM (1979) Mechanism of cardiodepression in endotoxin shock. Circ Shock [Suppl] 1: 1–8
Cunnion RE, Schaer GL, Parker MM, Natanson C, Parrillo JE (1986) The coronary circulation in human septic shock. Circulation 73: 637–644
Dhainaut JF, Huyghenbaert MF, Monsallier JF, et al. (1987) Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation 75: 533–541
Parrillo JE, Burch C, Shelhamer JH, et al. (1985) A circulating myocardial depressant substance in humans with septic shock. J Clin Invest 76: 1539–1553
Schuette WH, Burch C, Roach P, Parrillo JE (1987) Closed loop television tracking of beating heart cells in vitro. Cytometry 8: 101–103
Reilly JM, Burch-Whitman C, Parker MM, et al. (1987) Characteristics of a myocardial depressant substance in patients with septic shock. Circulation 76 (Part II): IV - 164 (Abstract)
Mason JW, Kleeberg U, Dolan P, et al. (1970) Plasma kallikrein and Hageman factor in gram-negative bacteremia. Ann Intern Med 73: 545–551
Vick JA, Mehlman B, Heiffer MH (1971) Early histamine release and death due to endotoxin (35690). Proc Soc Exp Biol Med 137: 902–906
Krause SM, Hess ML (1979) Diphenhydramine protection of the failing myocardium during gram-negative endotoxemia. Circ Shock 6: 75–87
Jacob HS, Craddock PR, Hammerschmidt DE, et al. (1980) Complement-induced granulocyte aggregation. N Engl J Med 302: 789–794
Ognibene FP, Parker MM, Burch-Whitman C, et al. (1988) Neutrophil aggregating activity and septic shock in humans. J Crit Care 3: 103–111
Danner RL, Elin RJ, Hosseini JM, et al. (1987) The effect of endotoxemia on the clinical manifestations of septic shock ( SS) in humans. Clin Res 35: 384A (Abstract)
Danner RL, Joiner KA, Parrillo JE (1987) Inhibition of endotoxin-induced priming of human neutrophils by lipid X and 3-Aza-lipid X. J Clin Invest 80: 605–612
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© 1989 Springer-Verlag Berlin Heidelberg
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Parker, M.M., Parrillo, J.E. (1989). Sepsis and Myocardial Function. In: Reinhart, K., Eyrich, K. (eds) Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83083-9_12
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DOI: https://doi.org/10.1007/978-3-642-83083-9_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83085-3
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